Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study

Abstract We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord...

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Autores principales:	Qi-fan Zhou, Meng-xiao Zhang, Shi-lu Tong, Rui-xue Tao, Jia-hu Hao, Kun Huang, Fang-biao Tao, Peng Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6084983fe80a42ea8a4b063c53dbd90b
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spelling	oai:doaj.org-article:6084983fe80a42ea8a4b063c53dbd90b2021-12-02T12:32:26ZMaternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study10.1038/s41598-017-01778-12045-2322https://doaj.org/article/6084983fe80a42ea8a4b063c53dbd90b2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01778-1https://doaj.org/toc/2045-2322Abstract We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (25(OH)D) were measured in 1491 mother-infant pairs. Data on maternal sociodemographic characteristics, health status, lifestyle and birth outcomes were prospectively collected. For infants born in winter-spring, the infants of MD mothers had significantly reduced concentrations of 25(OH) D (adjusted β = −3.51 nmol/L; 95% CI: −6.19, −0.84; P = 0.010) and lower birth weight (3267 ± 470 g vs 3348 ± 598 g, F = 4.64, P = 0.031), compared with the infants of NMD mothers. A significant, inverse linear relationship was noted between maternal depression scores and the concentration of 25(OH)D for infants born in winter-spring (adjusted β = −0.158; 95% CI: −0.259, −0.057). The significant, inverse linear relationship between maternal depression scores and fetomaternal ratios of 25(OH) D was also observed among the infants born in winter-spring (adjusted β = −0.005; 95% CI: −0.008, −0.003). MD appears to significantly attenuate the vitamin D concentrations and birth weight of infants born in winter-spring. A decreased fetomaternal ratio of 25(OH)D might be involved in this biological pathway.Qi-fan ZhouMeng-xiao ZhangShi-lu TongRui-xue TaoJia-hu HaoKun HuangFang-biao TaoPeng ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qi-fan Zhou Meng-xiao Zhang Shi-lu Tong Rui-xue Tao Jia-hu Hao Kun Huang Fang-biao Tao Peng Zhu Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study
description	Abstract We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (25(OH)D) were measured in 1491 mother-infant pairs. Data on maternal sociodemographic characteristics, health status, lifestyle and birth outcomes were prospectively collected. For infants born in winter-spring, the infants of MD mothers had significantly reduced concentrations of 25(OH) D (adjusted β = −3.51 nmol/L; 95% CI: −6.19, −0.84; P = 0.010) and lower birth weight (3267 ± 470 g vs 3348 ± 598 g, F = 4.64, P = 0.031), compared with the infants of NMD mothers. A significant, inverse linear relationship was noted between maternal depression scores and the concentration of 25(OH)D for infants born in winter-spring (adjusted β = −0.158; 95% CI: −0.259, −0.057). The significant, inverse linear relationship between maternal depression scores and fetomaternal ratios of 25(OH) D was also observed among the infants born in winter-spring (adjusted β = −0.005; 95% CI: −0.008, −0.003). MD appears to significantly attenuate the vitamin D concentrations and birth weight of infants born in winter-spring. A decreased fetomaternal ratio of 25(OH)D might be involved in this biological pathway.
format	article
author	Qi-fan Zhou Meng-xiao Zhang Shi-lu Tong Rui-xue Tao Jia-hu Hao Kun Huang Fang-biao Tao Peng Zhu
author_facet	Qi-fan Zhou Meng-xiao Zhang Shi-lu Tong Rui-xue Tao Jia-hu Hao Kun Huang Fang-biao Tao Peng Zhu
author_sort	Qi-fan Zhou
title	Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study
title_short	Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study
title_full	Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study
title_fullStr	Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study
title_full_unstemmed	Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study
title_sort	maternal depression attenuates newborn vitamin d concentrations in winter-spring: a prospective population-based study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6084983fe80a42ea8a4b063c53dbd90b
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_version_	1718394096890937344

Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study

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