TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia

Hülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is used to further investigate p190RhoGAP-dependent reg...

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Autores principales:	Maren Hülsemann, Colline Sanchez, Polina V. Verkhusha, Vera Des Marais, Serena P. H. Mao, Sara K. Donnelly, Jeffrey E. Segall, Louis Hodgson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/608534c3193740aaa779560f505d5296
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spelling	oai:doaj.org-article:608534c3193740aaa779560f505d52962021-12-02T18:50:02ZTC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia10.1038/s42003-021-02583-32399-3642https://doaj.org/article/608534c3193740aaa779560f505d52962021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02583-3https://doaj.org/toc/2399-3642Hülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is used to further investigate p190RhoGAP-dependent regulation of spatiotemporal TC10 activity.Maren HülsemannColline SanchezPolina V. VerkhushaVera Des MaraisSerena P. H. MaoSara K. DonnellyJeffrey E. SegallLouis HodgsonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maren Hülsemann Colline Sanchez Polina V. Verkhusha Vera Des Marais Serena P. H. Mao Sara K. Donnelly Jeffrey E. Segall Louis Hodgson TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
description	Hülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is used to further investigate p190RhoGAP-dependent regulation of spatiotemporal TC10 activity.
format	article
author	Maren Hülsemann Colline Sanchez Polina V. Verkhusha Vera Des Marais Serena P. H. Mao Sara K. Donnelly Jeffrey E. Segall Louis Hodgson
author_facet	Maren Hülsemann Colline Sanchez Polina V. Verkhusha Vera Des Marais Serena P. H. Mao Sara K. Donnelly Jeffrey E. Segall Louis Hodgson
author_sort	Maren Hülsemann
title	TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
title_short	TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
title_full	TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
title_fullStr	TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
title_full_unstemmed	TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
title_sort	tc10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/608534c3193740aaa779560f505d5296
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TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia

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