Structural and functional thalamocortical connectivity study in female fibromyalgia

Abstract Dysfunctional thalamocortical interactions have been suggested as putative mechanisms of ineffective pain modulation and also suggested as possible pathophysiology of fibromyalgia (FM). However, it remains unclear which specific thalamocortical networks are altered and whether it is related...

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Autores principales:	Dajung J. Kim, Manyoel Lim, June Sic Kim, Chun Kee Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/608581409d54407dbeb0720375b6fa7c
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spelling	oai:doaj.org-article:608581409d54407dbeb0720375b6fa7c2021-12-05T12:14:03ZStructural and functional thalamocortical connectivity study in female fibromyalgia10.1038/s41598-021-02616-12045-2322https://doaj.org/article/608581409d54407dbeb0720375b6fa7c2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02616-1https://doaj.org/toc/2045-2322Abstract Dysfunctional thalamocortical interactions have been suggested as putative mechanisms of ineffective pain modulation and also suggested as possible pathophysiology of fibromyalgia (FM). However, it remains unclear which specific thalamocortical networks are altered and whether it is related to abnormal pain perception in people with FM. Here, we conducted combined vertex-wise subcortical shape, cortical thickness, structural covariance, and resting-state functional connectivity analyses to address these questions. FM group exhibited a regional shape deflation of the left posterior thalamus encompassing the ventral posterior lateral and pulvinar nuclei. The structural covariance analysis showed that the extent of regional deflation of the left posterior thalamus was negatively covaried with the left inferior parietal cortical thickness in the FM group, whereas those two regions were positively covaried in the healthy controls. In functional connectivity analysis with the left posterior thalamus as a seed, FM group had less connectivity with the periaqueductal gray compared with healthy controls, but enhanced connectivity between the posterior thalamus and bilateral inferior parietal regions, associated with a lower electrical pain threshold at the hand dorsum (pain-free point). Overall, our findings showed the structural thalamic alteration interacts with the cortical regions in a functionally maladaptive direction, leading the FM brain more responsive to external stimuli and potentially contributing to pain amplification.Dajung J. KimManyoel LimJune Sic KimChun Kee ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dajung J. Kim Manyoel Lim June Sic Kim Chun Kee Chung Structural and functional thalamocortical connectivity study in female fibromyalgia
description	Abstract Dysfunctional thalamocortical interactions have been suggested as putative mechanisms of ineffective pain modulation and also suggested as possible pathophysiology of fibromyalgia (FM). However, it remains unclear which specific thalamocortical networks are altered and whether it is related to abnormal pain perception in people with FM. Here, we conducted combined vertex-wise subcortical shape, cortical thickness, structural covariance, and resting-state functional connectivity analyses to address these questions. FM group exhibited a regional shape deflation of the left posterior thalamus encompassing the ventral posterior lateral and pulvinar nuclei. The structural covariance analysis showed that the extent of regional deflation of the left posterior thalamus was negatively covaried with the left inferior parietal cortical thickness in the FM group, whereas those two regions were positively covaried in the healthy controls. In functional connectivity analysis with the left posterior thalamus as a seed, FM group had less connectivity with the periaqueductal gray compared with healthy controls, but enhanced connectivity between the posterior thalamus and bilateral inferior parietal regions, associated with a lower electrical pain threshold at the hand dorsum (pain-free point). Overall, our findings showed the structural thalamic alteration interacts with the cortical regions in a functionally maladaptive direction, leading the FM brain more responsive to external stimuli and potentially contributing to pain amplification.
format	article
author	Dajung J. Kim Manyoel Lim June Sic Kim Chun Kee Chung
author_facet	Dajung J. Kim Manyoel Lim June Sic Kim Chun Kee Chung
author_sort	Dajung J. Kim
title	Structural and functional thalamocortical connectivity study in female fibromyalgia
title_short	Structural and functional thalamocortical connectivity study in female fibromyalgia
title_full	Structural and functional thalamocortical connectivity study in female fibromyalgia
title_fullStr	Structural and functional thalamocortical connectivity study in female fibromyalgia
title_full_unstemmed	Structural and functional thalamocortical connectivity study in female fibromyalgia
title_sort	structural and functional thalamocortical connectivity study in female fibromyalgia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/608581409d54407dbeb0720375b6fa7c
work_keys_str_mv	AT dajungjkim structuralandfunctionalthalamocorticalconnectivitystudyinfemalefibromyalgia AT manyoellim structuralandfunctionalthalamocorticalconnectivitystudyinfemalefibromyalgia AT junesickim structuralandfunctionalthalamocorticalconnectivitystudyinfemalefibromyalgia AT chunkeechung structuralandfunctionalthalamocorticalconnectivitystudyinfemalefibromyalgia
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Structural and functional thalamocortical connectivity study in female fibromyalgia

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