The Role of Immune Cells in Oxi-Inflamm-Aging

Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade...

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Autores principales:	Irene Martínez de Toda, Noemi Ceprián, Estefanía Díaz-Del Cerro, Mónica De la Fuente
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aging immune cells oxidative stress inflammatory stress biological age Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6086a0a7a2154d7e846695d9544ecb70
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spelling	oai:doaj.org-article:6086a0a7a2154d7e846695d9544ecb702021-11-25T17:09:56ZThe Role of Immune Cells in Oxi-Inflamm-Aging10.3390/cells101129742073-4409https://doaj.org/article/6086a0a7a2154d7e846695d9544ecb702021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2974https://doaj.org/toc/2073-4409Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade chronic inflammation throughout the immune system’s activity. It is known that the immune system weakens with age, which increases morbidity and mortality. In this context, we describe how the function of immune cells can be used as an indicator of the rate of aging of an individual. In addition to this passive role as a marker, we describe how the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging) and inducing senescence in far tissue cells. Further supporting our theory, we discuss how certain lifestyle conditions (such as social environment, nutrition, or exercise) can have an impact on longevity by affecting the oxidative and inflammatory state of immune cells, regulating immunosenescence and its contribution to oxi-inflamm-aging.Irene Martínez de TodaNoemi CepriánEstefanía Díaz-Del CerroMónica De la FuenteMDPI AGarticleagingimmune cellsoxidative stressinflammatory stressbiological ageBiology (General)QH301-705.5ENCells, Vol 10, Iss 2974, p 2974 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging immune cells oxidative stress inflammatory stress biological age Biology (General) QH301-705.5
spellingShingle	aging immune cells oxidative stress inflammatory stress biological age Biology (General) QH301-705.5 Irene Martínez de Toda Noemi Ceprián Estefanía Díaz-Del Cerro Mónica De la Fuente The Role of Immune Cells in Oxi-Inflamm-Aging
description	Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade chronic inflammation throughout the immune system’s activity. It is known that the immune system weakens with age, which increases morbidity and mortality. In this context, we describe how the function of immune cells can be used as an indicator of the rate of aging of an individual. In addition to this passive role as a marker, we describe how the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging) and inducing senescence in far tissue cells. Further supporting our theory, we discuss how certain lifestyle conditions (such as social environment, nutrition, or exercise) can have an impact on longevity by affecting the oxidative and inflammatory state of immune cells, regulating immunosenescence and its contribution to oxi-inflamm-aging.
format	article
author	Irene Martínez de Toda Noemi Ceprián Estefanía Díaz-Del Cerro Mónica De la Fuente
author_facet	Irene Martínez de Toda Noemi Ceprián Estefanía Díaz-Del Cerro Mónica De la Fuente
author_sort	Irene Martínez de Toda
title	The Role of Immune Cells in Oxi-Inflamm-Aging
title_short	The Role of Immune Cells in Oxi-Inflamm-Aging
title_full	The Role of Immune Cells in Oxi-Inflamm-Aging
title_fullStr	The Role of Immune Cells in Oxi-Inflamm-Aging
title_full_unstemmed	The Role of Immune Cells in Oxi-Inflamm-Aging
title_sort	role of immune cells in oxi-inflamm-aging
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6086a0a7a2154d7e846695d9544ecb70
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The Role of Immune Cells in Oxi-Inflamm-Aging

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