The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans

Abstract Low temperature has a great impact on animal life. Homoiotherms such as mammals increase their energy expenditure to produce heat by activating the cAMP-protein kinase A (PKA)-hormone-sensitive lipase (HSL) pathway under cold stress. Although poikilothermic animals do not have the ability t...

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Autores principales:	Fang Liu, Yi Xiao, Xing-Lai Ji, Ke-Qin Zhang, Cheng-Gang Zou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6087771228924ea292d5390969396283
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spelling	oai:doaj.org-article:6087771228924ea292d53909693962832021-12-02T12:31:58ZThe cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans10.1038/s41598-017-00630-w2045-2322https://doaj.org/article/6087771228924ea292d53909693962832017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00630-whttps://doaj.org/toc/2045-2322Abstract Low temperature has a great impact on animal life. Homoiotherms such as mammals increase their energy expenditure to produce heat by activating the cAMP-protein kinase A (PKA)-hormone-sensitive lipase (HSL) pathway under cold stress. Although poikilothermic animals do not have the ability to regulate body temperature, whether this pathway is required for cold tolerance remains unknown. We have now achieved this using the genetically tractable model animal Caenorhabditis elegans. We demonstrate that cold stress activates PKA signaling, which in turn up-regulates the expression of a hormone-sensitive lipase hosl-1. The lipase induces fat mobilization, leading to glycerol accumulation, thereby protecting worms against cold stress. Our findings provide an example of an evolutionarily conserved mechanism for cold tolerance that has persisted in both poikilothermic and homoeothermic animals.Fang LiuYi XiaoXing-Lai JiKe-Qin ZhangCheng-Gang ZouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fang Liu Yi Xiao Xing-Lai Ji Ke-Qin Zhang Cheng-Gang Zou The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
description	Abstract Low temperature has a great impact on animal life. Homoiotherms such as mammals increase their energy expenditure to produce heat by activating the cAMP-protein kinase A (PKA)-hormone-sensitive lipase (HSL) pathway under cold stress. Although poikilothermic animals do not have the ability to regulate body temperature, whether this pathway is required for cold tolerance remains unknown. We have now achieved this using the genetically tractable model animal Caenorhabditis elegans. We demonstrate that cold stress activates PKA signaling, which in turn up-regulates the expression of a hormone-sensitive lipase hosl-1. The lipase induces fat mobilization, leading to glycerol accumulation, thereby protecting worms against cold stress. Our findings provide an example of an evolutionarily conserved mechanism for cold tolerance that has persisted in both poikilothermic and homoeothermic animals.
format	article
author	Fang Liu Yi Xiao Xing-Lai Ji Ke-Qin Zhang Cheng-Gang Zou
author_facet	Fang Liu Yi Xiao Xing-Lai Ji Ke-Qin Zhang Cheng-Gang Zou
author_sort	Fang Liu
title	The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
title_short	The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
title_full	The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
title_fullStr	The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
title_full_unstemmed	The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
title_sort	camp-pka pathway-mediated fat mobilization is required for cold tolerance in c. elegans
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6087771228924ea292d5390969396283
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The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans

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