Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer

An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to e...

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Autores principales:	Zhongci Hang, Tong Lei, Zehua Zeng, Shanglin Cai, Wangyu Bi, Hongwu Du
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Alzheimer's disease Parkinson's disease Cancer Intestinal flora Fecal microbiota transplantation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6087cfc770ef4b2fb208e551d28fe7f7
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spelling	oai:doaj.org-article:6087cfc770ef4b2fb208e551d28fe7f72021-12-02T04:59:05ZComposition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer0753-332210.1016/j.biopha.2021.112343https://doaj.org/article/6087cfc770ef4b2fb208e551d28fe7f72022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011276https://doaj.org/toc/0753-3322An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases.Zhongci HangTong LeiZehua ZengShanglin CaiWangyu BiHongwu DuElsevierarticleAlzheimer's diseaseParkinson's diseaseCancerIntestinal floraFecal microbiota transplantationTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112343- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer's disease Parkinson's disease Cancer Intestinal flora Fecal microbiota transplantation Therapeutics. Pharmacology RM1-950
spellingShingle	Alzheimer's disease Parkinson's disease Cancer Intestinal flora Fecal microbiota transplantation Therapeutics. Pharmacology RM1-950 Zhongci Hang Tong Lei Zehua Zeng Shanglin Cai Wangyu Bi Hongwu Du Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
description	An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases.
format	article
author	Zhongci Hang Tong Lei Zehua Zeng Shanglin Cai Wangyu Bi Hongwu Du
author_facet	Zhongci Hang Tong Lei Zehua Zeng Shanglin Cai Wangyu Bi Hongwu Du
author_sort	Zhongci Hang
title	Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
title_short	Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
title_full	Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
title_fullStr	Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
title_full_unstemmed	Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
title_sort	composition of intestinal flora affects the risk relationship between alzheimer's disease/parkinson's disease and cancer
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/6087cfc770ef4b2fb208e551d28fe7f7
work_keys_str_mv	AT zhongcihang compositionofintestinalfloraaffectstheriskrelationshipbetweenalzheimersdiseaseparkinsonsdiseaseandcancer AT tonglei compositionofintestinalfloraaffectstheriskrelationshipbetweenalzheimersdiseaseparkinsonsdiseaseandcancer AT zehuazeng compositionofintestinalfloraaffectstheriskrelationshipbetweenalzheimersdiseaseparkinsonsdiseaseandcancer AT shanglincai compositionofintestinalfloraaffectstheriskrelationshipbetweenalzheimersdiseaseparkinsonsdiseaseandcancer AT wangyubi compositionofintestinalfloraaffectstheriskrelationshipbetweenalzheimersdiseaseparkinsonsdiseaseandcancer AT hongwudu compositionofintestinalfloraaffectstheriskrelationshipbetweenalzheimersdiseaseparkinsonsdiseaseandcancer
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Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer

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