CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.

Cluster of differentiation 14 (CD14) gene is an important component of the human innate immune system and its role in tuberculosis (TB) has been sparsely documented. The enhanced plasma CD14 levels in TB patients as compared to healthy controls are associated with CD14 gene promoter (C-159T) polymor...

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Autores principales:	M Y Areeshi, Raju K Mandal, Aditya K Panda, Shekhar C Bisht, Shafiul Haque
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/608da41171b744b99807f128d95abd61
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spelling	oai:doaj.org-article:608da41171b744b99807f128d95abd612021-11-18T07:43:34ZCD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.1932-620310.1371/journal.pone.0064747https://doaj.org/article/608da41171b744b99807f128d95abd612013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741383/?tool=EBIhttps://doaj.org/toc/1932-6203Cluster of differentiation 14 (CD14) gene is an important component of the human innate immune system and its role in tuberculosis (TB) has been sparsely documented. The enhanced plasma CD14 levels in TB patients as compared to healthy controls are associated with CD14 gene promoter (C-159T) polymorphism. In the past few years, the relationship between CD14 -159 C>T (rs2569190) polymorphism and risk of TB has been reported in various ethnic populations; however, those studies have yielded contradictory results. In this study systemic assessment was done for the published studies based on the association between CD14 -159 C>T polymorphism and TB risk retrieved from PubMed (Medline) and EMBASE search. A total number of 1389 TB cases and 1421 controls were included in this study and meta-analysis was performed to elucidate the association between CD14 -159 C>T polymorphism and its susceptibility towards TB. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele contrast, homozygous comparison, heterozygous comparison, dominant and recessive genetic model. It was found that T allele carrier was significantly associated with increased TB risk (T vs. C: p-value = 0.023; OR = 1.305, 95% CI = 1.038 to 1.640). Similarly, homozygous mutant TT genotype also revealed 1.6 fold increased risk of TB (TT vs. CC; p-value = 0.040; OR = 1.652, 95% CI = 1.023 to 2.667). Additionally, dominant genetic model demonstrated increased risk of developing TB (TT vs. CC+CT: p-value = 0.006; OR = 1.585, 95% CI = 1.142 to 2.201). The study demonstrates that CD14 gene (-159 C>T) polymorphism contributes increased susceptibility for TB. Moreover, this meta-analysis also suggests for future larger studies with stratified case control population and biological characterization for validation studies.M Y AreeshiRaju K MandalAditya K PandaShekhar C BishtShafiul HaquePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64747 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M Y Areeshi Raju K Mandal Aditya K Panda Shekhar C Bisht Shafiul Haque CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.
description	Cluster of differentiation 14 (CD14) gene is an important component of the human innate immune system and its role in tuberculosis (TB) has been sparsely documented. The enhanced plasma CD14 levels in TB patients as compared to healthy controls are associated with CD14 gene promoter (C-159T) polymorphism. In the past few years, the relationship between CD14 -159 C>T (rs2569190) polymorphism and risk of TB has been reported in various ethnic populations; however, those studies have yielded contradictory results. In this study systemic assessment was done for the published studies based on the association between CD14 -159 C>T polymorphism and TB risk retrieved from PubMed (Medline) and EMBASE search. A total number of 1389 TB cases and 1421 controls were included in this study and meta-analysis was performed to elucidate the association between CD14 -159 C>T polymorphism and its susceptibility towards TB. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele contrast, homozygous comparison, heterozygous comparison, dominant and recessive genetic model. It was found that T allele carrier was significantly associated with increased TB risk (T vs. C: p-value = 0.023; OR = 1.305, 95% CI = 1.038 to 1.640). Similarly, homozygous mutant TT genotype also revealed 1.6 fold increased risk of TB (TT vs. CC; p-value = 0.040; OR = 1.652, 95% CI = 1.023 to 2.667). Additionally, dominant genetic model demonstrated increased risk of developing TB (TT vs. CC+CT: p-value = 0.006; OR = 1.585, 95% CI = 1.142 to 2.201). The study demonstrates that CD14 gene (-159 C>T) polymorphism contributes increased susceptibility for TB. Moreover, this meta-analysis also suggests for future larger studies with stratified case control population and biological characterization for validation studies.
format	article
author	M Y Areeshi Raju K Mandal Aditya K Panda Shekhar C Bisht Shafiul Haque
author_facet	M Y Areeshi Raju K Mandal Aditya K Panda Shekhar C Bisht Shafiul Haque
author_sort	M Y Areeshi
title	CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.
title_short	CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.
title_full	CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.
title_fullStr	CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.
title_full_unstemmed	CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.
title_sort	cd14 -159 c>t gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/608da41171b744b99807f128d95abd61
work_keys_str_mv	AT myareeshi cd14159ctgenepolymorphismwithincreasedriskoftuberculosisevidencefromametaanalysis AT rajukmandal cd14159ctgenepolymorphismwithincreasedriskoftuberculosisevidencefromametaanalysis AT adityakpanda cd14159ctgenepolymorphismwithincreasedriskoftuberculosisevidencefromametaanalysis AT shekharcbisht cd14159ctgenepolymorphismwithincreasedriskoftuberculosisevidencefromametaanalysis AT shafiulhaque cd14159ctgenepolymorphismwithincreasedriskoftuberculosisevidencefromametaanalysis
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CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis.

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