Expression patterns and prognostic value of RUNX genes in kidney cancer

Abstract Kidney cancer is the third most common malignancy of the urinary system, of which, kidney renal clear cell carcinoma (KIRC) accounts for the vast majority. Runt-related transcription factors (RUNX) are involved in multiple cellular functions. However, the diverse expression patterns and pro...

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Autores principales:	Ke Gao, Fang Zhang, Ke Chen, Wei Li, Yi-Bing Guan, Meng-Lu Xu, Tie Chong, Zhi-Ming Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60903e5f750440399d288bfbd616d407
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spelling	oai:doaj.org-article:60903e5f750440399d288bfbd616d4072021-12-02T16:26:23ZExpression patterns and prognostic value of RUNX genes in kidney cancer10.1038/s41598-021-94294-22045-2322https://doaj.org/article/60903e5f750440399d288bfbd616d4072021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94294-2https://doaj.org/toc/2045-2322Abstract Kidney cancer is the third most common malignancy of the urinary system, of which, kidney renal clear cell carcinoma (KIRC) accounts for the vast majority. Runt-related transcription factors (RUNX) are involved in multiple cellular functions. However, the diverse expression patterns and prognostic values of RUNX genes in kidney cancer remained to be elucidated. In our study, we mined the DNA methylation, transcriptional and survival data of RUNX genes in patients with different kinds of kidney cancer through Oncomine, Gene Expression Profiling Interactive Analysis, UALCAN, Kaplan–Meier Plotter, cBioPortal and LinkedOmics. We found that RUNX1 and RUNX3 were upregulated in KIRC tissues compared with those in normal tissues. The survival analysis results indicated a high transcription level of RUNX1 was associated with poor overall survival (OS) in KIRC patients. Furthermore, KIRC tumor tissues had significantly lower levels of RUNX1 promoter methylation than that in paracancerous tissues, with decreased DNA methylation of RUNX1 notably associated with poor OS in KIRC. In conclusion, our results revealed that RUNX1 may be a potential therapeutic target for treating KIRC, and RUNX1 promoter methylation level shows promise as a novel diagnostic and prognostic biomarker, which laid a foundation for further study.Ke GaoFang ZhangKe ChenWei LiYi-Bing GuanMeng-Lu XuTie ChongZhi-Ming DaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ke Gao Fang Zhang Ke Chen Wei Li Yi-Bing Guan Meng-Lu Xu Tie Chong Zhi-Ming Dai Expression patterns and prognostic value of RUNX genes in kidney cancer
description	Abstract Kidney cancer is the third most common malignancy of the urinary system, of which, kidney renal clear cell carcinoma (KIRC) accounts for the vast majority. Runt-related transcription factors (RUNX) are involved in multiple cellular functions. However, the diverse expression patterns and prognostic values of RUNX genes in kidney cancer remained to be elucidated. In our study, we mined the DNA methylation, transcriptional and survival data of RUNX genes in patients with different kinds of kidney cancer through Oncomine, Gene Expression Profiling Interactive Analysis, UALCAN, Kaplan–Meier Plotter, cBioPortal and LinkedOmics. We found that RUNX1 and RUNX3 were upregulated in KIRC tissues compared with those in normal tissues. The survival analysis results indicated a high transcription level of RUNX1 was associated with poor overall survival (OS) in KIRC patients. Furthermore, KIRC tumor tissues had significantly lower levels of RUNX1 promoter methylation than that in paracancerous tissues, with decreased DNA methylation of RUNX1 notably associated with poor OS in KIRC. In conclusion, our results revealed that RUNX1 may be a potential therapeutic target for treating KIRC, and RUNX1 promoter methylation level shows promise as a novel diagnostic and prognostic biomarker, which laid a foundation for further study.
format	article
author	Ke Gao Fang Zhang Ke Chen Wei Li Yi-Bing Guan Meng-Lu Xu Tie Chong Zhi-Ming Dai
author_facet	Ke Gao Fang Zhang Ke Chen Wei Li Yi-Bing Guan Meng-Lu Xu Tie Chong Zhi-Ming Dai
author_sort	Ke Gao
title	Expression patterns and prognostic value of RUNX genes in kidney cancer
title_short	Expression patterns and prognostic value of RUNX genes in kidney cancer
title_full	Expression patterns and prognostic value of RUNX genes in kidney cancer
title_fullStr	Expression patterns and prognostic value of RUNX genes in kidney cancer
title_full_unstemmed	Expression patterns and prognostic value of RUNX genes in kidney cancer
title_sort	expression patterns and prognostic value of runx genes in kidney cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/60903e5f750440399d288bfbd616d407
work_keys_str_mv	AT kegao expressionpatternsandprognosticvalueofrunxgenesinkidneycancer AT fangzhang expressionpatternsandprognosticvalueofrunxgenesinkidneycancer AT kechen expressionpatternsandprognosticvalueofrunxgenesinkidneycancer AT weili expressionpatternsandprognosticvalueofrunxgenesinkidneycancer AT yibingguan expressionpatternsandprognosticvalueofrunxgenesinkidneycancer AT mengluxu expressionpatternsandprognosticvalueofrunxgenesinkidneycancer AT tiechong expressionpatternsandprognosticvalueofrunxgenesinkidneycancer AT zhimingdai expressionpatternsandprognosticvalueofrunxgenesinkidneycancer
_version_	1718384054551707648

Expression patterns and prognostic value of RUNX genes in kidney cancer

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