Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling

Innate intratumoral immunity might be important in enhancing oncolytic tumor immunotherapy. Here, the authors show that recombinant poliovirus signalling through TBK-IRF3 enhances tumor-infiltrating T cell activity and multi-cytokine function.

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Autores principales:	Michael C. Brown, Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, Georgia M. Beasley, E. Shelley Hwang, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60906122327e4f2e9beced154e87cbb7
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spelling	oai:doaj.org-article:60906122327e4f2e9beced154e87cbb72021-12-02T16:35:53ZViral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling10.1038/s41467-021-22088-12041-1723https://doaj.org/article/60906122327e4f2e9beced154e87cbb72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22088-1https://doaj.org/toc/2041-1723Innate intratumoral immunity might be important in enhancing oncolytic tumor immunotherapy. Here, the authors show that recombinant poliovirus signalling through TBK-IRF3 enhances tumor-infiltrating T cell activity and multi-cytokine function.Michael C. BrownMubeen M. MosahebMalte MohmeZachary P. McKayEda K. HollJonathan P. KastanYuanfan YangGeorgia M. BeasleyE. Shelley HwangDavid M. AshleyDarell D. BignerSmita K. NairMatthias GromeierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael C. Brown Mubeen M. Mosaheb Malte Mohme Zachary P. McKay Eda K. Holl Jonathan P. Kastan Yuanfan Yang Georgia M. Beasley E. Shelley Hwang David M. Ashley Darell D. Bigner Smita K. Nair Matthias Gromeier Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
description	Innate intratumoral immunity might be important in enhancing oncolytic tumor immunotherapy. Here, the authors show that recombinant poliovirus signalling through TBK-IRF3 enhances tumor-infiltrating T cell activity and multi-cytokine function.
format	article
author	Michael C. Brown Mubeen M. Mosaheb Malte Mohme Zachary P. McKay Eda K. Holl Jonathan P. Kastan Yuanfan Yang Georgia M. Beasley E. Shelley Hwang David M. Ashley Darell D. Bigner Smita K. Nair Matthias Gromeier
author_facet	Michael C. Brown Mubeen M. Mosaheb Malte Mohme Zachary P. McKay Eda K. Holl Jonathan P. Kastan Yuanfan Yang Georgia M. Beasley E. Shelley Hwang David M. Ashley Darell D. Bigner Smita K. Nair Matthias Gromeier
author_sort	Michael C. Brown
title	Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
title_short	Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
title_full	Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
title_fullStr	Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
title_full_unstemmed	Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
title_sort	viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective tbk1-irf3 signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/60906122327e4f2e9beced154e87cbb7
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Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling

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