The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors

Abstract. Suhartono S, Ismail YS, Muhayya SR. 2019. The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors. Biodiversitas 20: 3000-3004. The infections attenuated by the presence of virulence factors might be facilitated by quorum sensing (QS) mec...

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Autores principales:	Suhartono Suhartono, Yulia Sari Ismail, Syarifah Raisha Muhayya
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2019
Materias:	moringa oleifera, quorum sensing, virulence factors Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/60917d9dfd774be496c11917275f3238
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spelling	oai:doaj.org-article:60917d9dfd774be496c11917275f32382021-11-21T21:54:58ZThe interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors1412-033X2085-472210.13057/biodiv/d201031https://doaj.org/article/60917d9dfd774be496c11917275f32382019-09-01T00:00:00Zhttps://smujo.id/biodiv/article/view/4405https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Suhartono S, Ismail YS, Muhayya SR. 2019. The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors. Biodiversitas 20: 3000-3004. The infections attenuated by the presence of virulence factors might be facilitated by quorum sensing (QS) mechanism. The continuous treatments of bacterial infections with current drugs, however, has developed such pathogenic bacteria more antibiotic-resistant, encouraging to searching for better alternative treatment, such as the use of plant-derived bioactive constituents, including kelor (Moringa oleifera L.). In the present research, kelor (M. oleifera) ethanolic leaf extract was evaluated for their potency as an antibacterial agent to inhibit bacterial virulence factors mediated by quorum sensing mechanism against Chromobacterium violaceum and Pseudomonas aeruginosa PAO1. A phytochemical examination of M. oleifera leaf-ethanolic extracts has been conducted resulting positive detection of alkaloids, steroids, terpenoids, flavonoids, and phenolics or tannins. The extracts had MIC and MBC values of 10 mg/mL and 20 mg/mL, respectively, for both tested bacteria. The ethanolic extracts of M. oleifera leaves also showed potent inhibition of quorum sensing by significantly reducing violacein and pyocyanin production as well as interference of swarming motility and biofilm formation.Suhartono SuhartonoYulia Sari IsmailSyarifah Raisha MuhayyaMBI & UNS Soloarticlemoringa oleifera, quorum sensing, virulence factorsBiology (General)QH301-705.5ENBiodiversitas, Vol 20, Iss 10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	moringa oleifera, quorum sensing, virulence factors Biology (General) QH301-705.5
spellingShingle	moringa oleifera, quorum sensing, virulence factors Biology (General) QH301-705.5 Suhartono Suhartono Yulia Sari Ismail Syarifah Raisha Muhayya The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors
description	Abstract. Suhartono S, Ismail YS, Muhayya SR. 2019. The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors. Biodiversitas 20: 3000-3004. The infections attenuated by the presence of virulence factors might be facilitated by quorum sensing (QS) mechanism. The continuous treatments of bacterial infections with current drugs, however, has developed such pathogenic bacteria more antibiotic-resistant, encouraging to searching for better alternative treatment, such as the use of plant-derived bioactive constituents, including kelor (Moringa oleifera L.). In the present research, kelor (M. oleifera) ethanolic leaf extract was evaluated for their potency as an antibacterial agent to inhibit bacterial virulence factors mediated by quorum sensing mechanism against Chromobacterium violaceum and Pseudomonas aeruginosa PAO1. A phytochemical examination of M. oleifera leaf-ethanolic extracts has been conducted resulting positive detection of alkaloids, steroids, terpenoids, flavonoids, and phenolics or tannins. The extracts had MIC and MBC values of 10 mg/mL and 20 mg/mL, respectively, for both tested bacteria. The ethanolic extracts of M. oleifera leaves also showed potent inhibition of quorum sensing by significantly reducing violacein and pyocyanin production as well as interference of swarming motility and biofilm formation.
format	article
author	Suhartono Suhartono Yulia Sari Ismail Syarifah Raisha Muhayya
author_facet	Suhartono Suhartono Yulia Sari Ismail Syarifah Raisha Muhayya
author_sort	Suhartono Suhartono
title	The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors
title_short	The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors
title_full	The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors
title_fullStr	The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors
title_full_unstemmed	The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors
title_sort	interference of moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors
publisher	MBI & UNS Solo
publishDate	2019
url	https://doaj.org/article/60917d9dfd774be496c11917275f3238
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The interference of Moringa oleifera leaf extracts to modulate quorum sensing-facilitated virulence factors

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