Toxin import through the antibiotic efflux channel TolC

Bacteria can secrete diffusible protein toxins that kill competing bacteria. Here, the authors use biochemical, biophysical and structural analyses to show how one of these toxins exploits TolC (a major antibiotic efflux channel) to transport itself across the outer membrane of target cells.

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Detalles Bibliográficos
Autores principales:	Nicholas G. Housden, Melissa N. Webby, Edward D. Lowe, Tarick J. El-Baba, Renata Kaminska, Christina Redfield, Carol V. Robinson, Colin Kleanthous
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6092256deab845dc8d7e5e28d0ee37c4
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spelling	oai:doaj.org-article:6092256deab845dc8d7e5e28d0ee37c42021-12-02T16:31:04ZToxin import through the antibiotic efflux channel TolC10.1038/s41467-021-24930-y2041-1723https://doaj.org/article/6092256deab845dc8d7e5e28d0ee37c42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24930-yhttps://doaj.org/toc/2041-1723Bacteria can secrete diffusible protein toxins that kill competing bacteria. Here, the authors use biochemical, biophysical and structural analyses to show how one of these toxins exploits TolC (a major antibiotic efflux channel) to transport itself across the outer membrane of target cells.Nicholas G. HousdenMelissa N. WebbyEdward D. LoweTarick J. El-BabaRenata KaminskaChristina RedfieldCarol V. RobinsonColin KleanthousNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas G. Housden Melissa N. Webby Edward D. Lowe Tarick J. El-Baba Renata Kaminska Christina Redfield Carol V. Robinson Colin Kleanthous Toxin import through the antibiotic efflux channel TolC
description	Bacteria can secrete diffusible protein toxins that kill competing bacteria. Here, the authors use biochemical, biophysical and structural analyses to show how one of these toxins exploits TolC (a major antibiotic efflux channel) to transport itself across the outer membrane of target cells.
format	article
author	Nicholas G. Housden Melissa N. Webby Edward D. Lowe Tarick J. El-Baba Renata Kaminska Christina Redfield Carol V. Robinson Colin Kleanthous
author_facet	Nicholas G. Housden Melissa N. Webby Edward D. Lowe Tarick J. El-Baba Renata Kaminska Christina Redfield Carol V. Robinson Colin Kleanthous
author_sort	Nicholas G. Housden
title	Toxin import through the antibiotic efflux channel TolC
title_short	Toxin import through the antibiotic efflux channel TolC
title_full	Toxin import through the antibiotic efflux channel TolC
title_fullStr	Toxin import through the antibiotic efflux channel TolC
title_full_unstemmed	Toxin import through the antibiotic efflux channel TolC
title_sort	toxin import through the antibiotic efflux channel tolc
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6092256deab845dc8d7e5e28d0ee37c4
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Toxin import through the antibiotic efflux channel TolC

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