Influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters

Abstract Data collection of mechanical parameters from compressive tests play a fundamental role in FE modelling of bone tissues or the developing and designing of bone implants, especially referring to osteoporosis or other forms of bone loss. A total of 43 cylindrical samples (Ø8 × 16 mm) were tak...

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Autores principales:	F. Metzner, C. Neupetsch, J.-P. Fischer, W.-G. Drossel, C.-E. Heyde, S. Schleifenbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/609400037f364cf4bd0f0a1edf07df5b
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spelling	oai:doaj.org-article:609400037f364cf4bd0f0a1edf07df5b2021-12-02T17:14:24ZInfluence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters10.1038/s41598-021-92685-z2045-2322https://doaj.org/article/609400037f364cf4bd0f0a1edf07df5b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92685-zhttps://doaj.org/toc/2045-2322Abstract Data collection of mechanical parameters from compressive tests play a fundamental role in FE modelling of bone tissues or the developing and designing of bone implants, especially referring to osteoporosis or other forms of bone loss. A total of 43 cylindrical samples (Ø8 × 16 mm) were taken from 43 freshly frozen proximal femora using a tenon cutter. All femora underwent BMD measurement and additionally apparent- and relative- and bulk density (ρapp, ρr, ρb) were determined using samples bordering the compressive specimen on the proximal and distal regions. All samples were classified as "normal", "osteopenia" and "osteoporosis" based on the DEXA measurements. Distal apparent density was most suitable for predicting bone strength and BMD. One novel aspect is the examination of the plateau stress as it describes the stress at which the failure of spongious bone progresses. No significant differences in mechanical properties (compressive modulus E; compressive stress σmax and plateau stress σp) were found between osteopenic and osteoporotic bone. The results suggest that already in the case of a known osteopenia, actions should be taken as they are applied in the case of osteoporosis A review of the literature regarding extraction and testing methods illustrates the urgent need for standardized biomechanical compressive material testing.F. MetznerC. NeupetschJ.-P. FischerW.-G. DrosselC.-E. HeydeS. SchleifenbaumNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. Metzner C. Neupetsch J.-P. Fischer W.-G. Drossel C.-E. Heyde S. Schleifenbaum Influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters
description	Abstract Data collection of mechanical parameters from compressive tests play a fundamental role in FE modelling of bone tissues or the developing and designing of bone implants, especially referring to osteoporosis or other forms of bone loss. A total of 43 cylindrical samples (Ø8 × 16 mm) were taken from 43 freshly frozen proximal femora using a tenon cutter. All femora underwent BMD measurement and additionally apparent- and relative- and bulk density (ρapp, ρr, ρb) were determined using samples bordering the compressive specimen on the proximal and distal regions. All samples were classified as "normal", "osteopenia" and "osteoporosis" based on the DEXA measurements. Distal apparent density was most suitable for predicting bone strength and BMD. One novel aspect is the examination of the plateau stress as it describes the stress at which the failure of spongious bone progresses. No significant differences in mechanical properties (compressive modulus E; compressive stress σmax and plateau stress σp) were found between osteopenic and osteoporotic bone. The results suggest that already in the case of a known osteopenia, actions should be taken as they are applied in the case of osteoporosis A review of the literature regarding extraction and testing methods illustrates the urgent need for standardized biomechanical compressive material testing.
format	article
author	F. Metzner C. Neupetsch J.-P. Fischer W.-G. Drossel C.-E. Heyde S. Schleifenbaum
author_facet	F. Metzner C. Neupetsch J.-P. Fischer W.-G. Drossel C.-E. Heyde S. Schleifenbaum
author_sort	F. Metzner
title	Influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters
title_short	Influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters
title_full	Influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters
title_fullStr	Influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters
title_full_unstemmed	Influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters
title_sort	influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/609400037f364cf4bd0f0a1edf07df5b
work_keys_str_mv	AT fmetzner influenceofosteoporosisonthecompressivepropertiesoffemoralcancellousboneanditsdependenceonvariousdensityparameters AT cneupetsch influenceofosteoporosisonthecompressivepropertiesoffemoralcancellousboneanditsdependenceonvariousdensityparameters AT jpfischer influenceofosteoporosisonthecompressivepropertiesoffemoralcancellousboneanditsdependenceonvariousdensityparameters AT wgdrossel influenceofosteoporosisonthecompressivepropertiesoffemoralcancellousboneanditsdependenceonvariousdensityparameters AT ceheyde influenceofosteoporosisonthecompressivepropertiesoffemoralcancellousboneanditsdependenceonvariousdensityparameters AT sschleifenbaum influenceofosteoporosisonthecompressivepropertiesoffemoralcancellousboneanditsdependenceonvariousdensityparameters
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Influence of osteoporosis on the compressive properties of femoral cancellous bone and its dependence on various density parameters

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