Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer

Pancreatic cancer is one of the deadliest cancers worldwide, with a 5-year survival rate of less than 10%. This dismal survival rate can be attributed to several factors including insufficient diagnostics, rapid metastasis and chemoresistance. To identify new treatment options for improved patient o...

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Autores principales:	Akbar Lulu Marzan, Sarah Elizabeth Stewart
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pancreatic cancer biomarkers extracellular vesicles microvesicles exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/60964c917a794ac29cc7843a6018ec31
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spelling	oai:doaj.org-article:60964c917a794ac29cc7843a6018ec312021-11-25T17:02:29ZElucidating the Role of Extracellular Vesicles in Pancreatic Cancer10.3390/cancers132256692072-6694https://doaj.org/article/60964c917a794ac29cc7843a6018ec312021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5669https://doaj.org/toc/2072-6694Pancreatic cancer is one of the deadliest cancers worldwide, with a 5-year survival rate of less than 10%. This dismal survival rate can be attributed to several factors including insufficient diagnostics, rapid metastasis and chemoresistance. To identify new treatment options for improved patient outcomes, it is crucial to investigate the underlying mechanisms that contribute to pancreatic cancer progression. Accumulating evidence suggests that extracellular vesicles, including exosomes and microvesicles, are critical players in pancreatic cancer progression and chemoresistance. In addition, extracellular vesicles also have the potential to serve as promising biomarkers, therapeutic targets and drug delivery tools for the treatment of pancreatic cancer. In this review, we aim to summarise the current knowledge on the role of extracellular vesicles in pancreatic cancer progression, metastasis, immunity, metabolic dysfunction and chemoresistance, and discuss their potential roles as biomarkers for early diagnosis and drug delivery vehicles for treatment of pancreatic cancer.Akbar Lulu MarzanSarah Elizabeth StewartMDPI AGarticlepancreatic cancerbiomarkersextracellular vesiclesmicrovesiclesexosomesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5669, p 5669 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic cancer biomarkers extracellular vesicles microvesicles exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	pancreatic cancer biomarkers extracellular vesicles microvesicles exosomes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Akbar Lulu Marzan Sarah Elizabeth Stewart Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer
description	Pancreatic cancer is one of the deadliest cancers worldwide, with a 5-year survival rate of less than 10%. This dismal survival rate can be attributed to several factors including insufficient diagnostics, rapid metastasis and chemoresistance. To identify new treatment options for improved patient outcomes, it is crucial to investigate the underlying mechanisms that contribute to pancreatic cancer progression. Accumulating evidence suggests that extracellular vesicles, including exosomes and microvesicles, are critical players in pancreatic cancer progression and chemoresistance. In addition, extracellular vesicles also have the potential to serve as promising biomarkers, therapeutic targets and drug delivery tools for the treatment of pancreatic cancer. In this review, we aim to summarise the current knowledge on the role of extracellular vesicles in pancreatic cancer progression, metastasis, immunity, metabolic dysfunction and chemoresistance, and discuss their potential roles as biomarkers for early diagnosis and drug delivery vehicles for treatment of pancreatic cancer.
format	article
author	Akbar Lulu Marzan Sarah Elizabeth Stewart
author_facet	Akbar Lulu Marzan Sarah Elizabeth Stewart
author_sort	Akbar Lulu Marzan
title	Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer
title_short	Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer
title_full	Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer
title_fullStr	Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer
title_full_unstemmed	Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer
title_sort	elucidating the role of extracellular vesicles in pancreatic cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/60964c917a794ac29cc7843a6018ec31
work_keys_str_mv	AT akbarlulumarzan elucidatingtheroleofextracellularvesiclesinpancreaticcancer AT sarahelizabethstewart elucidatingtheroleofextracellularvesiclesinpancreaticcancer
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Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer

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