A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.
Glycated hemoglobin A1C (HbA1C) level is used as a diagnostic marker for diabetes mellitus and a predictor of diabetes associated complications. Genome-wide association studies have identified genetic variants associated with HbA1C level. Most of these studies have been conducted in populations of E...
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2013
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oai:doaj.org-article:60964d72adbc4b3f9a9d07c36378fa812021-11-18T08:47:52ZA study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.1932-620310.1371/journal.pone.0079767https://doaj.org/article/60964d72adbc4b3f9a9d07c36378fa812013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244560/?tool=EBIhttps://doaj.org/toc/1932-6203Glycated hemoglobin A1C (HbA1C) level is used as a diagnostic marker for diabetes mellitus and a predictor of diabetes associated complications. Genome-wide association studies have identified genetic variants associated with HbA1C level. Most of these studies have been conducted in populations of European ancestry. Here we report the findings from a meta-analysis of genome-wide association studies of HbA1C levels in 6,682 non-diabetic subjects of Chinese, Malay and South Asian ancestries. We also sought to examine the associations between HbA1C associated SNPs and microvascular complications associated with diabetes mellitus, namely chronic kidney disease and retinopathy. A cluster of 6 SNPs on chromosome 17 showed an association with HbA1C which achieved genome-wide significance in the Malays but not in Chinese and Asian Indians. No other variants achieved genome-wide significance in the individual studies or in the meta-analysis. When we investigated the reproducibility of the findings that emerged from the European studies, six loci out of fifteen were found to be associated with HbA1C with effect sizes similar to those reported in the populations of European ancestry and P-value ≤ 0.05. No convincing associations with chronic kidney disease and retinopathy were identified in this study.Peng ChenRick Twee-Hee OngWan-Ting TayXueling SimMohammad AliHaiyan XuChen SuoJianjun LiuKee-Seng ChiaEranga VithanaTerri L YoungTin AungWei-Yen LimChiea-Chuen KhorChing-Yu ChengTien-Yin WongYik-Ying TeoE-Shyong TaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79767 (2013) |
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| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Peng Chen Rick Twee-Hee Ong Wan-Ting Tay Xueling Sim Mohammad Ali Haiyan Xu Chen Suo Jianjun Liu Kee-Seng Chia Eranga Vithana Terri L Young Tin Aung Wei-Yen Lim Chiea-Chuen Khor Ching-Yu Cheng Tien-Yin Wong Yik-Ying Teo E-Shyong Tai A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. |
| description |
Glycated hemoglobin A1C (HbA1C) level is used as a diagnostic marker for diabetes mellitus and a predictor of diabetes associated complications. Genome-wide association studies have identified genetic variants associated with HbA1C level. Most of these studies have been conducted in populations of European ancestry. Here we report the findings from a meta-analysis of genome-wide association studies of HbA1C levels in 6,682 non-diabetic subjects of Chinese, Malay and South Asian ancestries. We also sought to examine the associations between HbA1C associated SNPs and microvascular complications associated with diabetes mellitus, namely chronic kidney disease and retinopathy. A cluster of 6 SNPs on chromosome 17 showed an association with HbA1C which achieved genome-wide significance in the Malays but not in Chinese and Asian Indians. No other variants achieved genome-wide significance in the individual studies or in the meta-analysis. When we investigated the reproducibility of the findings that emerged from the European studies, six loci out of fifteen were found to be associated with HbA1C with effect sizes similar to those reported in the populations of European ancestry and P-value ≤ 0.05. No convincing associations with chronic kidney disease and retinopathy were identified in this study. |
| format |
article |
| author |
Peng Chen Rick Twee-Hee Ong Wan-Ting Tay Xueling Sim Mohammad Ali Haiyan Xu Chen Suo Jianjun Liu Kee-Seng Chia Eranga Vithana Terri L Young Tin Aung Wei-Yen Lim Chiea-Chuen Khor Ching-Yu Cheng Tien-Yin Wong Yik-Ying Teo E-Shyong Tai |
| author_facet |
Peng Chen Rick Twee-Hee Ong Wan-Ting Tay Xueling Sim Mohammad Ali Haiyan Xu Chen Suo Jianjun Liu Kee-Seng Chia Eranga Vithana Terri L Young Tin Aung Wei-Yen Lim Chiea-Chuen Khor Ching-Yu Cheng Tien-Yin Wong Yik-Ying Teo E-Shyong Tai |
| author_sort |
Peng Chen |
| title |
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. |
| title_short |
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. |
| title_full |
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. |
| title_fullStr |
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. |
| title_full_unstemmed |
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry. |
| title_sort |
study assessing the association of glycated hemoglobin a1c (hba1c) associated variants with hba1c, chronic kidney disease and diabetic retinopathy in populations of asian ancestry. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/60964d72adbc4b3f9a9d07c36378fa81 |
| work_keys_str_mv |
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