COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder

Yuka Otsuka,1 Shingo Kakeda,2 Koichiro Sugimoto,2 Asuka Katsuki,1 Le Hoa Nguyen,1 Ryohei Igata,1 Keita Watanabe,2 Issei Ueda,2 Taro Kishi,3 Nakao Iwata,3 Yukunori Korogi,2 Reiji Yoshimura11Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Department o...

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Autores principales:	Otsuka Y, Kakeda S, Sugimoto K, Katsuki A, Nguyen LH, Igata R, Watanabe K, Ueda I, Kishi T, Iwata N, Korogi Y, Yoshimura R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	major depressive disorder COMT gene brain morphology hippocampal subfields volume subiculum surface-based morphometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/609728cd0fd840769f7230cae70fb03c
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spelling	oai:doaj.org-article:609728cd0fd840769f7230cae70fb03c2021-12-02T02:58:53ZCOMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder1178-2021https://doaj.org/article/609728cd0fd840769f7230cae70fb03c2019-06-01T00:00:00Zhttps://www.dovepress.com/comt-polymorphism-regulates-the-hippocampal-subfield-volumes-in-first--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yuka Otsuka,1 Shingo Kakeda,2 Koichiro Sugimoto,2 Asuka Katsuki,1 Le Hoa Nguyen,1 Ryohei Igata,1 Keita Watanabe,2 Issei Ueda,2 Taro Kishi,3 Nakao Iwata,3 Yukunori Korogi,2 Reiji Yoshimura11Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan; 3Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, JapanPurpose: Compared with healthy subjects (HS), patients with major depressive disorder (MDD) exhibit volume differences that affect the volume changes in several areas such as the limbic, cortical, subcortical, and white matter. Catechol-O-methyltransferase (COMT) is a methylation enzyme that catalyzes endogenous catecholamines. The Val158Met polymorphism of COMT has been reported to affect the dopamine (DA) levels, which plays an important role in psychiatric diseases. However, the relationships among both DA levels, COMT genotype, and brain morphology are complicated and controversial. In previous studies that investigated the hippocampal subfields, the greatest brain abnormalities in MDD patients were observed in Cornu Ammonis (CA)1 and the subiculum, followed by that in CA2-3. We have prospectively demonstrated the relationship between the single-nucleotide polymorphism of the Val158Met COMT gene (rs4680) and the hippocampal subfields in drug-naive MDD patients.Patients and methods: In this study, we compared 27 MDD patients and 42 HS who were divided into groups based on their COMT genotype. The effects of the diagnosis, genotype, and genotype–diagnosis interaction related to CA1 and the subiculum volumes, as well as the whole-brain cortical thickness, were evaluated by performing a FreeSurfer statistical analysis of high-resolution magnetic resonance imaging (MRI) findings.Results: The results revealed that there was a statistically significant interaction between the effects of diagnosis and genotype on the right subiculum (a component of the hippocampus).Conclusion: This Val158Met COMT polymorphism may influence the subiculum volume in drug-naive, first-episode MDD patients.Keywords: major depressive disorder, COMT gene, brain morphology, hippocampal subfields volume, subiculum, surface-based morphometryOtsuka YKakeda SSugimoto KKatsuki ANguyen LHIgata RWatanabe KUeda IKishi TIwata NKorogi YYoshimura RDove Medical Pressarticlemajor depressive disorderCOMT genebrain morphologyhippocampal subfields volumesubiculumsurface-based morphometryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1537-1545 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder COMT gene brain morphology hippocampal subfields volume subiculum surface-based morphometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depressive disorder COMT gene brain morphology hippocampal subfields volume subiculum surface-based morphometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Otsuka Y Kakeda S Sugimoto K Katsuki A Nguyen LH Igata R Watanabe K Ueda I Kishi T Iwata N Korogi Y Yoshimura R COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
description	Yuka Otsuka,1 Shingo Kakeda,2 Koichiro Sugimoto,2 Asuka Katsuki,1 Le Hoa Nguyen,1 Ryohei Igata,1 Keita Watanabe,2 Issei Ueda,2 Taro Kishi,3 Nakao Iwata,3 Yukunori Korogi,2 Reiji Yoshimura11Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan; 3Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, JapanPurpose: Compared with healthy subjects (HS), patients with major depressive disorder (MDD) exhibit volume differences that affect the volume changes in several areas such as the limbic, cortical, subcortical, and white matter. Catechol-O-methyltransferase (COMT) is a methylation enzyme that catalyzes endogenous catecholamines. The Val158Met polymorphism of COMT has been reported to affect the dopamine (DA) levels, which plays an important role in psychiatric diseases. However, the relationships among both DA levels, COMT genotype, and brain morphology are complicated and controversial. In previous studies that investigated the hippocampal subfields, the greatest brain abnormalities in MDD patients were observed in Cornu Ammonis (CA)1 and the subiculum, followed by that in CA2-3. We have prospectively demonstrated the relationship between the single-nucleotide polymorphism of the Val158Met COMT gene (rs4680) and the hippocampal subfields in drug-naive MDD patients.Patients and methods: In this study, we compared 27 MDD patients and 42 HS who were divided into groups based on their COMT genotype. The effects of the diagnosis, genotype, and genotype–diagnosis interaction related to CA1 and the subiculum volumes, as well as the whole-brain cortical thickness, were evaluated by performing a FreeSurfer statistical analysis of high-resolution magnetic resonance imaging (MRI) findings.Results: The results revealed that there was a statistically significant interaction between the effects of diagnosis and genotype on the right subiculum (a component of the hippocampus).Conclusion: This Val158Met COMT polymorphism may influence the subiculum volume in drug-naive, first-episode MDD patients.Keywords: major depressive disorder, COMT gene, brain morphology, hippocampal subfields volume, subiculum, surface-based morphometry
format	article
author	Otsuka Y Kakeda S Sugimoto K Katsuki A Nguyen LH Igata R Watanabe K Ueda I Kishi T Iwata N Korogi Y Yoshimura R
author_facet	Otsuka Y Kakeda S Sugimoto K Katsuki A Nguyen LH Igata R Watanabe K Ueda I Kishi T Iwata N Korogi Y Yoshimura R
author_sort	Otsuka Y
title	COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
title_short	COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
title_full	COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
title_fullStr	COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
title_full_unstemmed	COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
title_sort	comt polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/609728cd0fd840769f7230cae70fb03c
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COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder

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