Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change

Abstract Emphysema is a major pathological change in chronic obstructive pulmonary disease (COPD). However, the annual changes in the progression of emphysematous have not been investigated. We aimed to determine possible baseline predicting factors of the change in emphysematous progression in a su...

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Autores principales:	Akihiro Tsutsumi, Shotaro Chubachi, Hidehiro Irie, Mamoru Sasaki, Yoshitake Yamada, Hiroaki Sugiura, Masahiro Jinzaki, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku, Koichi Fukunaga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6098c81928a242edbe428a884c92310e
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spelling	oai:doaj.org-article:6098c81928a242edbe428a884c92310e2021-12-02T14:29:04ZCharacteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change10.1038/s41598-021-87724-82045-2322https://doaj.org/article/6098c81928a242edbe428a884c92310e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87724-8https://doaj.org/toc/2045-2322Abstract Emphysema is a major pathological change in chronic obstructive pulmonary disease (COPD). However, the annual changes in the progression of emphysematous have not been investigated. We aimed to determine possible baseline predicting factors of the change in emphysematous progression in a subgroup of COPD patients who demonstrated rapid progression. In this observational study, we analyzed patients with COPD who were followed up by computed tomography (CT) at least two times over a 3-year period (n = 217). We divided the annual change in the low attenuation area percentage (LAA%) into quartiles and defined a rapid progression group (n = 54) and a non-progression group (n = 163). Predictors of future changes in emphysematous progression differed from predictors of high LAA% at baseline. On multivariate logistic regression analysis, low blood eosinophilic count (odds ratio [OR], 3.22; P = 0.04) and having osteoporosis (OR, 2.13; P = 0.03) were related to rapid changes in emphysematous progression. There was no difference in baseline nutritional parameters, but nutritional parameters deteriorated in parallel with changes in emphysematous progression. Herein, we clarified the predictors of changes in emphysematous progression and concomitant deterioration of nutritional status in COPD patients.Akihiro TsutsumiShotaro ChubachiHidehiro IrieMamoru SasakiYoshitake YamadaHiroaki SugiuraMasahiro JinzakiHidetoshi NakamuraKoichiro AsanoTomoko BetsuyakuKoichi FukunagaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Akihiro Tsutsumi Shotaro Chubachi Hidehiro Irie Mamoru Sasaki Yoshitake Yamada Hiroaki Sugiura Masahiro Jinzaki Hidetoshi Nakamura Koichiro Asano Tomoko Betsuyaku Koichi Fukunaga Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change
description	Abstract Emphysema is a major pathological change in chronic obstructive pulmonary disease (COPD). However, the annual changes in the progression of emphysematous have not been investigated. We aimed to determine possible baseline predicting factors of the change in emphysematous progression in a subgroup of COPD patients who demonstrated rapid progression. In this observational study, we analyzed patients with COPD who were followed up by computed tomography (CT) at least two times over a 3-year period (n = 217). We divided the annual change in the low attenuation area percentage (LAA%) into quartiles and defined a rapid progression group (n = 54) and a non-progression group (n = 163). Predictors of future changes in emphysematous progression differed from predictors of high LAA% at baseline. On multivariate logistic regression analysis, low blood eosinophilic count (odds ratio [OR], 3.22; P = 0.04) and having osteoporosis (OR, 2.13; P = 0.03) were related to rapid changes in emphysematous progression. There was no difference in baseline nutritional parameters, but nutritional parameters deteriorated in parallel with changes in emphysematous progression. Herein, we clarified the predictors of changes in emphysematous progression and concomitant deterioration of nutritional status in COPD patients.
format	article
author	Akihiro Tsutsumi Shotaro Chubachi Hidehiro Irie Mamoru Sasaki Yoshitake Yamada Hiroaki Sugiura Masahiro Jinzaki Hidetoshi Nakamura Koichiro Asano Tomoko Betsuyaku Koichi Fukunaga
author_facet	Akihiro Tsutsumi Shotaro Chubachi Hidehiro Irie Mamoru Sasaki Yoshitake Yamada Hiroaki Sugiura Masahiro Jinzaki Hidetoshi Nakamura Koichiro Asano Tomoko Betsuyaku Koichi Fukunaga
author_sort	Akihiro Tsutsumi
title	Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change
title_short	Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change
title_full	Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change
title_fullStr	Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change
title_full_unstemmed	Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change
title_sort	characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6098c81928a242edbe428a884c92310e
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Characteristics of chronic obstructive pulmonary disease patients with robust progression of emphysematous change

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