Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

Glial cells are essential for functionality of the nervous system. Growing evidence underscores the importance of astrocytes; however, analogous astroglia in peripheral organs are poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis in a zebrafish model, we identify...

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Autores principales:	Nina L. Kikel-Coury, Jacob P. Brandt, Isabel A. Correia, Michael R. O’Dea, Dana F. DeSantis, Felicity Sterling, Kevin Vaughan, Gulberk Ozcebe, Pinar Zorlutuna, Cody J. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/609df6ba686a41dbaf1e4e3c3a90b968
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spelling	oai:doaj.org-article:609df6ba686a41dbaf1e4e3c3a90b9682021-11-25T05:33:59ZIdentification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function1544-91731545-7885https://doaj.org/article/609df6ba686a41dbaf1e4e3c3a90b9682021-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601506/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Glial cells are essential for functionality of the nervous system. Growing evidence underscores the importance of astrocytes; however, analogous astroglia in peripheral organs are poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis in a zebrafish model, we identify a neural crest–derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3 to drive differentiation and regulate heart rate and rhythm. Nexus glia are labeled with gfap, glast, and glutamine synthetase, markers that typically denote astroglia cells. Further, analysis of single-cell sequencing datasets of human and murine hearts across ages reveals astrocyte-like cells, which we confirm through a multispecies approach. We show that cardiac nexus glia at the outflow tract are critical regulators of both the sympathetic and parasympathetic system. These data establish the crucial role of glia on cardiac homeostasis and provide a description of nexus glia in the PNS. Do astrocyte-like cells exist in the peripheral nervous system? This study reveals that astrocyte-like cells termed cardiac nexus glia populate the heart, and that these cells are important for cardiac homeostasis, modulating heart rate and rhythm during development.Nina L. Kikel-CouryJacob P. BrandtIsabel A. CorreiaMichael R. O’DeaDana F. DeSantisFelicity SterlingKevin VaughanGulberk OzcebePinar ZorlutunaCody J. SmithPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nina L. Kikel-Coury Jacob P. Brandt Isabel A. Correia Michael R. O’Dea Dana F. DeSantis Felicity Sterling Kevin Vaughan Gulberk Ozcebe Pinar Zorlutuna Cody J. Smith Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
description	Glial cells are essential for functionality of the nervous system. Growing evidence underscores the importance of astrocytes; however, analogous astroglia in peripheral organs are poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis in a zebrafish model, we identify a neural crest–derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3 to drive differentiation and regulate heart rate and rhythm. Nexus glia are labeled with gfap, glast, and glutamine synthetase, markers that typically denote astroglia cells. Further, analysis of single-cell sequencing datasets of human and murine hearts across ages reveals astrocyte-like cells, which we confirm through a multispecies approach. We show that cardiac nexus glia at the outflow tract are critical regulators of both the sympathetic and parasympathetic system. These data establish the crucial role of glia on cardiac homeostasis and provide a description of nexus glia in the PNS. Do astrocyte-like cells exist in the peripheral nervous system? This study reveals that astrocyte-like cells termed cardiac nexus glia populate the heart, and that these cells are important for cardiac homeostasis, modulating heart rate and rhythm during development.
format	article
author	Nina L. Kikel-Coury Jacob P. Brandt Isabel A. Correia Michael R. O’Dea Dana F. DeSantis Felicity Sterling Kevin Vaughan Gulberk Ozcebe Pinar Zorlutuna Cody J. Smith
author_facet	Nina L. Kikel-Coury Jacob P. Brandt Isabel A. Correia Michael R. O’Dea Dana F. DeSantis Felicity Sterling Kevin Vaughan Gulberk Ozcebe Pinar Zorlutuna Cody J. Smith
author_sort	Nina L. Kikel-Coury
title	Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
title_short	Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
title_full	Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
title_fullStr	Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
title_full_unstemmed	Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
title_sort	identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/609df6ba686a41dbaf1e4e3c3a90b968
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Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

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