Topological impact of negative links on the stability of resting-state brain network

Abstract Stability is a physical attribute that stands opposite the change. However, it is still unclear how the arrangement of links called topology affects network stability. In this study, we tackled this issue in the resting-state brain network using structural balance. Structural balance theory...

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Main Authors:	Majid Saberi, Reza Khosrowabadi, Ali Khatibi, Bratislav Misic, Gholamreza Jafari
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/60a0a369a4394388a7f1f248231619a5
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spelling	oai:doaj.org-article:60a0a369a4394388a7f1f248231619a52021-12-02T10:47:54ZTopological impact of negative links on the stability of resting-state brain network10.1038/s41598-021-81767-72045-2322https://doaj.org/article/60a0a369a4394388a7f1f248231619a52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81767-7https://doaj.org/toc/2045-2322Abstract Stability is a physical attribute that stands opposite the change. However, it is still unclear how the arrangement of links called topology affects network stability. In this study, we tackled this issue in the resting-state brain network using structural balance. Structural balance theory employs the quality of triadic associations between signed links to determine the network stability. In this study, we showed that negative links of the resting-state network make hubs to reduce balance-energy and push the network into a more stable state compared to null-networks with trivial topologies. In this regard, we created a global measure entitled ‘tendency to make hub’ to assess the hubness of the network. Besides, we revealed nodal degrees of negative links have an exponential distribution that confirms the existence of negative hubs. Our findings indicate that the arrangement of negative links plays an important role in the balance (stability) of the resting-state brain network.Majid SaberiReza KhosrowabadiAli KhatibiBratislav MisicGholamreza JafariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Majid Saberi Reza Khosrowabadi Ali Khatibi Bratislav Misic Gholamreza Jafari Topological impact of negative links on the stability of resting-state brain network
description	Abstract Stability is a physical attribute that stands opposite the change. However, it is still unclear how the arrangement of links called topology affects network stability. In this study, we tackled this issue in the resting-state brain network using structural balance. Structural balance theory employs the quality of triadic associations between signed links to determine the network stability. In this study, we showed that negative links of the resting-state network make hubs to reduce balance-energy and push the network into a more stable state compared to null-networks with trivial topologies. In this regard, we created a global measure entitled ‘tendency to make hub’ to assess the hubness of the network. Besides, we revealed nodal degrees of negative links have an exponential distribution that confirms the existence of negative hubs. Our findings indicate that the arrangement of negative links plays an important role in the balance (stability) of the resting-state brain network.
format	article
author	Majid Saberi Reza Khosrowabadi Ali Khatibi Bratislav Misic Gholamreza Jafari
author_facet	Majid Saberi Reza Khosrowabadi Ali Khatibi Bratislav Misic Gholamreza Jafari
author_sort	Majid Saberi
title	Topological impact of negative links on the stability of resting-state brain network
title_short	Topological impact of negative links on the stability of resting-state brain network
title_full	Topological impact of negative links on the stability of resting-state brain network
title_fullStr	Topological impact of negative links on the stability of resting-state brain network
title_full_unstemmed	Topological impact of negative links on the stability of resting-state brain network
title_sort	topological impact of negative links on the stability of resting-state brain network
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/60a0a369a4394388a7f1f248231619a5
work_keys_str_mv	AT majidsaberi topologicalimpactofnegativelinksonthestabilityofrestingstatebrainnetwork AT rezakhosrowabadi topologicalimpactofnegativelinksonthestabilityofrestingstatebrainnetwork AT alikhatibi topologicalimpactofnegativelinksonthestabilityofrestingstatebrainnetwork AT bratislavmisic topologicalimpactofnegativelinksonthestabilityofrestingstatebrainnetwork AT gholamrezajafari topologicalimpactofnegativelinksonthestabilityofrestingstatebrainnetwork
_version_	1718396713954181120

Topological impact of negative links on the stability of resting-state brain network

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