Paracrine diffusion of PrP(C) and propagation of prion infectivity by plasma membrane-derived microvesicles.

Paracrine diffusion of PrP(C) and propagation of prion infectivity by plasma membrane-derived microvesicles.

Cellular prion protein (PrP(C)) is a physiological constituent of eukaryotic cells. The cellular pathways underlying prions spread from the sites of prions infection/peripheral replication to the central nervous system are still not elucidated. Membrane-derived microvesicles (MVs) are submicron (0.1...

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Bibliographic Details
Main Authors: Vincenzo Mattei, Maria Grazia Barenco, Vincenzo Tasciotti, Tina Garofalo, Agostina Longo, Klaus Boller, Johannes Löwer, Roberta Misasi, Fabio Montrasio, Maurizio Sorice
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2009
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/60a3d355fb45408eadee1c64f31a7544
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