Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP

Pop1 and 6 are subunits of RNase P and RNase MRP, which process ribosomal and tRNAs. The authors show that when Pop1 and 6 are impaired, the telomerase subunit Est1 binds telomerase RNA at normal levels, but the binding is unstable. As a result, nuclear import of the telomerase holoenzyme is inhibit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	P. Daniela Garcia, Robert W. Leach, Gable M. Wadsworth, Krishna Choudhary, Hua Li, Sharon Aviran, Harold D. Kim, Virginia A. Zakian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60a84cb1852b4201965cf90b77707313
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:60a84cb1852b4201965cf90b77707313
record_format	dspace
spelling	oai:doaj.org-article:60a84cb1852b4201965cf90b777073132021-12-02T15:37:18ZStability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP10.1038/s41467-020-15875-92041-1723https://doaj.org/article/60a84cb1852b4201965cf90b777073132020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15875-9https://doaj.org/toc/2041-1723Pop1 and 6 are subunits of RNase P and RNase MRP, which process ribosomal and tRNAs. The authors show that when Pop1 and 6 are impaired, the telomerase subunit Est1 binds telomerase RNA at normal levels, but the binding is unstable. As a result, nuclear import of the telomerase holoenzyme is inhibited.P. Daniela GarciaRobert W. LeachGable M. WadsworthKrishna ChoudharyHua LiSharon AviranHarold D. KimVirginia A. ZakianNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q P. Daniela Garcia Robert W. Leach Gable M. Wadsworth Krishna Choudhary Hua Li Sharon Aviran Harold D. Kim Virginia A. Zakian Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP
description	Pop1 and 6 are subunits of RNase P and RNase MRP, which process ribosomal and tRNAs. The authors show that when Pop1 and 6 are impaired, the telomerase subunit Est1 binds telomerase RNA at normal levels, but the binding is unstable. As a result, nuclear import of the telomerase holoenzyme is inhibited.
format	article
author	P. Daniela Garcia Robert W. Leach Gable M. Wadsworth Krishna Choudhary Hua Li Sharon Aviran Harold D. Kim Virginia A. Zakian
author_facet	P. Daniela Garcia Robert W. Leach Gable M. Wadsworth Krishna Choudhary Hua Li Sharon Aviran Harold D. Kim Virginia A. Zakian
author_sort	P. Daniela Garcia
title	Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP
title_short	Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP
title_full	Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP
title_fullStr	Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP
title_full_unstemmed	Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP
title_sort	stability and nuclear localization of yeast telomerase depend on protein components of rnase p/mrp
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/60a84cb1852b4201965cf90b77707313
work_keys_str_mv	AT pdanielagarcia stabilityandnuclearlocalizationofyeasttelomerasedependonproteincomponentsofrnasepmrp AT robertwleach stabilityandnuclearlocalizationofyeasttelomerasedependonproteincomponentsofrnasepmrp AT gablemwadsworth stabilityandnuclearlocalizationofyeasttelomerasedependonproteincomponentsofrnasepmrp AT krishnachoudhary stabilityandnuclearlocalizationofyeasttelomerasedependonproteincomponentsofrnasepmrp AT huali stabilityandnuclearlocalizationofyeasttelomerasedependonproteincomponentsofrnasepmrp AT sharonaviran stabilityandnuclearlocalizationofyeasttelomerasedependonproteincomponentsofrnasepmrp AT harolddkim stabilityandnuclearlocalizationofyeasttelomerasedependonproteincomponentsofrnasepmrp AT virginiaazakian stabilityandnuclearlocalizationofyeasttelomerasedependonproteincomponentsofrnasepmrp
_version_	1718386236074229760

Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP

Ejemplares similares