MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.
Virtually all of the elements of Mycobacterium tuberculosis (Mtb) pathogenesis, including pro-inflammatory cytokine production, granuloma formation, cachexia, and mortality, can be induced by its predominant cell wall glycolipid, trehalose 6,6'-dimycolate (TDM/cord factor). TDM mediates these p...
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Autores principales: | Dawn M E Bowdish, Kaori Sakamoto, Mi-Jeong Kim, Mariliis Kroos, Subhankar Mukhopadhyay, Cynthia A Leifer, Karl Tryggvason, Siamon Gordon, David G Russell |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2009
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Materias: | |
Acceso en línea: | https://doaj.org/article/60a95a690ee04b82925828e4ee023449 |
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