Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin

The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and animal models to demonstrate that the C2B domain...

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Autores principales:	Nicholas A. Courtney, Huan Bao, Joseph S. Briguglio, Edwin R. Chapman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1
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spelling	oai:doaj.org-article:60a9c376ca40470abac94a203d8f4cc12021-12-02T14:35:56ZSynaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin10.1038/s41467-019-12015-w2041-1723https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc12019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12015-whttps://doaj.org/toc/2041-1723The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and animal models to demonstrate that the C2B domain of syt1, and not complexin, is solely responsible for the reduction of the spontaneous release at the presynapseNicholas A. CourtneyHuan BaoJoseph S. BriguglioEdwin R. ChapmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas A. Courtney Huan Bao Joseph S. Briguglio Edwin R. Chapman Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
description	The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and animal models to demonstrate that the C2B domain of syt1, and not complexin, is solely responsible for the reduction of the spontaneous release at the presynapse
format	article
author	Nicholas A. Courtney Huan Bao Joseph S. Briguglio Edwin R. Chapman
author_facet	Nicholas A. Courtney Huan Bao Joseph S. Briguglio Edwin R. Chapman
author_sort	Nicholas A. Courtney
title	Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_short	Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_full	Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_fullStr	Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_full_unstemmed	Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
title_sort	synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1
work_keys_str_mv	AT nicholasacourtney synaptotagmin1clampssynapticvesiclefusioninmammalianneuronsindependentofcomplexin AT huanbao synaptotagmin1clampssynapticvesiclefusioninmammalianneuronsindependentofcomplexin AT josephsbriguglio synaptotagmin1clampssynapticvesiclefusioninmammalianneuronsindependentofcomplexin AT edwinrchapman synaptotagmin1clampssynapticvesiclefusioninmammalianneuronsindependentofcomplexin
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Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin

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