Using the T Cell Receptor as a Biomarker in Type 1 Diabetes

T cell receptors (TCRs) are unique markers that define antigen specificity for a given T cell. With the evolution of sequencing and computational analysis technologies, TCRs are now prime candidates for the development of next-generation non-cell based T cell biomarkers, which provide a surrogate me...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maki Nakayama, Aaron W. Michels
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	T cells TCR sequencing autoimmunity type 1 diabetes HLA MHC Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/60aa1c3c389c4b8aad4bb498f379bb27
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:60aa1c3c389c4b8aad4bb498f379bb27
record_format	dspace
spelling	oai:doaj.org-article:60aa1c3c389c4b8aad4bb498f379bb272021-11-17T05:02:50ZUsing the T Cell Receptor as a Biomarker in Type 1 Diabetes1664-322410.3389/fimmu.2021.777788https://doaj.org/article/60aa1c3c389c4b8aad4bb498f379bb272021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.777788/fullhttps://doaj.org/toc/1664-3224T cell receptors (TCRs) are unique markers that define antigen specificity for a given T cell. With the evolution of sequencing and computational analysis technologies, TCRs are now prime candidates for the development of next-generation non-cell based T cell biomarkers, which provide a surrogate measure to assess the presence of antigen-specific T cells. Type 1 diabetes (T1D), the immune-mediated form of diabetes, is a prototypical organ specific autoimmune disease in which T cells play a pivotal role in targeting pancreatic insulin-producing beta cells. While the disease is now predictable by measuring autoantibodies in the peripheral blood directed to beta cell proteins, there is an urgent need to develop T cell markers that recapitulate T cell activity in the pancreas and can be a measure of disease activity. This review focuses on the potential and challenges of developing TCR biomarkers for T1D. We summarize current knowledge about TCR repertoires and clonotypes specific for T1D and discuss challenges that are unique for autoimmune diabetes. Ultimately, the integration of large TCR datasets produced from individuals with and without T1D along with computational ‘big data’ analysis will facilitate the development of TCRs as potentially powerful biomarkers in the development of T1D.Maki NakayamaMaki NakayamaMaki NakayamaAaron W. MichelsAaron W. MichelsAaron W. MichelsAaron W. MichelsFrontiers Media S.A.articleT cellsTCR sequencingautoimmunitytype 1 diabetesHLAMHCImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	T cells TCR sequencing autoimmunity type 1 diabetes HLA MHC Immunologic diseases. Allergy RC581-607
spellingShingle	T cells TCR sequencing autoimmunity type 1 diabetes HLA MHC Immunologic diseases. Allergy RC581-607 Maki Nakayama Maki Nakayama Maki Nakayama Aaron W. Michels Aaron W. Michels Aaron W. Michels Aaron W. Michels Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
description	T cell receptors (TCRs) are unique markers that define antigen specificity for a given T cell. With the evolution of sequencing and computational analysis technologies, TCRs are now prime candidates for the development of next-generation non-cell based T cell biomarkers, which provide a surrogate measure to assess the presence of antigen-specific T cells. Type 1 diabetes (T1D), the immune-mediated form of diabetes, is a prototypical organ specific autoimmune disease in which T cells play a pivotal role in targeting pancreatic insulin-producing beta cells. While the disease is now predictable by measuring autoantibodies in the peripheral blood directed to beta cell proteins, there is an urgent need to develop T cell markers that recapitulate T cell activity in the pancreas and can be a measure of disease activity. This review focuses on the potential and challenges of developing TCR biomarkers for T1D. We summarize current knowledge about TCR repertoires and clonotypes specific for T1D and discuss challenges that are unique for autoimmune diabetes. Ultimately, the integration of large TCR datasets produced from individuals with and without T1D along with computational ‘big data’ analysis will facilitate the development of TCRs as potentially powerful biomarkers in the development of T1D.
format	article
author	Maki Nakayama Maki Nakayama Maki Nakayama Aaron W. Michels Aaron W. Michels Aaron W. Michels Aaron W. Michels
author_facet	Maki Nakayama Maki Nakayama Maki Nakayama Aaron W. Michels Aaron W. Michels Aaron W. Michels Aaron W. Michels
author_sort	Maki Nakayama
title	Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
title_short	Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
title_full	Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
title_fullStr	Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
title_full_unstemmed	Using the T Cell Receptor as a Biomarker in Type 1 Diabetes
title_sort	using the t cell receptor as a biomarker in type 1 diabetes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/60aa1c3c389c4b8aad4bb498f379bb27
work_keys_str_mv	AT makinakayama usingthetcellreceptorasabiomarkerintype1diabetes AT makinakayama usingthetcellreceptorasabiomarkerintype1diabetes AT makinakayama usingthetcellreceptorasabiomarkerintype1diabetes AT aaronwmichels usingthetcellreceptorasabiomarkerintype1diabetes AT aaronwmichels usingthetcellreceptorasabiomarkerintype1diabetes AT aaronwmichels usingthetcellreceptorasabiomarkerintype1diabetes AT aaronwmichels usingthetcellreceptorasabiomarkerintype1diabetes
_version_	1718425928217919488

Using the T Cell Receptor as a Biomarker in Type 1 Diabetes

Ejemplares similares