Epidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China.
<h4>Background</h4>Hepatitis E is caused by two viral genotype groups: human types and zoonotic types. Current understanding of the epidemiology of the zoonotic hepatitis E disease is founded largely on hospital-based studies.<h4>Methods</h4>The epidemiology of hepatitis E wa...
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oai:doaj.org-article:60aaf4bd99724873a0afefb10fe0122d2021-11-18T08:34:37ZEpidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China.1932-620310.1371/journal.pone.0087154https://doaj.org/article/60aaf4bd99724873a0afefb10fe0122d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498033/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Hepatitis E is caused by two viral genotype groups: human types and zoonotic types. Current understanding of the epidemiology of the zoonotic hepatitis E disease is founded largely on hospital-based studies.<h4>Methods</h4>The epidemiology of hepatitis E was investigated in a community-based surveillance study conducted over one year in a rural city in eastern China with a registered population of 400,162.<h4>Results</h4>The seroprevalence of hepatitis E in the cohort was 38%. The incidence of hepatitis E was 2.8/10,000 person-years. Totally 93.5% of the infections were attributed to genotype 4 and the rest, to genotype 1. Hepatitis E accounted for 28.4% (102/359) of the acute hepatitis cases and 68.9% (102/148) of the acute viral hepatitis cases in this area of China. The disease occurred sporadically with a higher prevalence during the cold season and in men, with the male-to-female ratio of 3∶1. Additionally, the incidence of hepatitis E increased with age. Hepatitis B virus carriers have an increased risk of contracting hepatitis E than the general population (OR = 2.5, 95%CI 1.5-4.2). Pre-existing immunity to hepatitis E lowered the risk (relative risk = 0.34, 95% CI 0.21-0.55) and reduced the severity of the disease.<h4>Conclusions</h4>Hepatitis E in the rural population of China is essentially that of a zoonosis due to the genotype 4 virus, the epidemiology of which is similar to that due to the other zoonotic genotype 3 virus.Feng-Cai ZhuShou-Jie HuangTing WuXue-Feng ZhangZhong-Ze WangXing AiQiang YanChang-Lin YangJia-Ping CaiHan-Min JiangYi-Jun WangMun-Hon NgJun ZhangNing-Shao XiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87154 (2014) |
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Medicine R Science Q |
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Medicine R Science Q Feng-Cai Zhu Shou-Jie Huang Ting Wu Xue-Feng Zhang Zhong-Ze Wang Xing Ai Qiang Yan Chang-Lin Yang Jia-Ping Cai Han-Min Jiang Yi-Jun Wang Mun-Hon Ng Jun Zhang Ning-Shao Xia Epidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China. |
| description |
<h4>Background</h4>Hepatitis E is caused by two viral genotype groups: human types and zoonotic types. Current understanding of the epidemiology of the zoonotic hepatitis E disease is founded largely on hospital-based studies.<h4>Methods</h4>The epidemiology of hepatitis E was investigated in a community-based surveillance study conducted over one year in a rural city in eastern China with a registered population of 400,162.<h4>Results</h4>The seroprevalence of hepatitis E in the cohort was 38%. The incidence of hepatitis E was 2.8/10,000 person-years. Totally 93.5% of the infections were attributed to genotype 4 and the rest, to genotype 1. Hepatitis E accounted for 28.4% (102/359) of the acute hepatitis cases and 68.9% (102/148) of the acute viral hepatitis cases in this area of China. The disease occurred sporadically with a higher prevalence during the cold season and in men, with the male-to-female ratio of 3∶1. Additionally, the incidence of hepatitis E increased with age. Hepatitis B virus carriers have an increased risk of contracting hepatitis E than the general population (OR = 2.5, 95%CI 1.5-4.2). Pre-existing immunity to hepatitis E lowered the risk (relative risk = 0.34, 95% CI 0.21-0.55) and reduced the severity of the disease.<h4>Conclusions</h4>Hepatitis E in the rural population of China is essentially that of a zoonosis due to the genotype 4 virus, the epidemiology of which is similar to that due to the other zoonotic genotype 3 virus. |
| format |
article |
| author |
Feng-Cai Zhu Shou-Jie Huang Ting Wu Xue-Feng Zhang Zhong-Ze Wang Xing Ai Qiang Yan Chang-Lin Yang Jia-Ping Cai Han-Min Jiang Yi-Jun Wang Mun-Hon Ng Jun Zhang Ning-Shao Xia |
| author_facet |
Feng-Cai Zhu Shou-Jie Huang Ting Wu Xue-Feng Zhang Zhong-Ze Wang Xing Ai Qiang Yan Chang-Lin Yang Jia-Ping Cai Han-Min Jiang Yi-Jun Wang Mun-Hon Ng Jun Zhang Ning-Shao Xia |
| author_sort |
Feng-Cai Zhu |
| title |
Epidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China. |
| title_short |
Epidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China. |
| title_full |
Epidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China. |
| title_fullStr |
Epidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China. |
| title_full_unstemmed |
Epidemiology of zoonotic hepatitis E: a community-based surveillance study in a rural population in China. |
| title_sort |
epidemiology of zoonotic hepatitis e: a community-based surveillance study in a rural population in china. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/60aaf4bd99724873a0afefb10fe0122d |
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