Feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.

Stereotactic ablative radiotherapy is being increasingly adopted in the treatment of lung tumors. The use of proton beam therapy can further reduce dose to normal structures. However, uncertainty exists in proton-based treatment plans, including range uncertainties, large sensitivity to position unc...

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Autores principales:	Benjamin Mou, Chris J Beltran, Sean S Park, Kenneth R Olivier, Keith M Furutani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60acd1a3f1734f14b8b1a024b939f1f2
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spelling	oai:doaj.org-article:60acd1a3f1734f14b8b1a024b939f1f22021-11-18T08:17:39ZFeasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.1932-620310.1371/journal.pone.0098621https://doaj.org/article/60acd1a3f1734f14b8b1a024b939f1f22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24887068/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Stereotactic ablative radiotherapy is being increasingly adopted in the treatment of lung tumors. The use of proton beam therapy can further reduce dose to normal structures. However, uncertainty exists in proton-based treatment plans, including range uncertainties, large sensitivity to position uncertainty, and calculation of dose deposition in heterogeneous areas. This study investigated the feasibility of proton transmission beams, i.e. without the Bragg peak, to treat lung tumors with stereotactic ablative radiotherapy. We compared three representative treatment plans using proton transmission beams versus conformal static-gantry photon beams. It was found that proton treatment plans using transmission beams passing through the patient were feasible and demonstrated lower dose to normal structures and markedly reduced treatment times than photon plans. This is the first study to demonstrate the feasibility of proton-based stereotactic ablative radiotherapy planning for lung tumors using proton transmission beams alone. Further research using this novel approach for proton-based planning is warranted.Benjamin MouChris J BeltranSean S ParkKenneth R OlivierKeith M FurutaniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98621 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benjamin Mou Chris J Beltran Sean S Park Kenneth R Olivier Keith M Furutani Feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.
description	Stereotactic ablative radiotherapy is being increasingly adopted in the treatment of lung tumors. The use of proton beam therapy can further reduce dose to normal structures. However, uncertainty exists in proton-based treatment plans, including range uncertainties, large sensitivity to position uncertainty, and calculation of dose deposition in heterogeneous areas. This study investigated the feasibility of proton transmission beams, i.e. without the Bragg peak, to treat lung tumors with stereotactic ablative radiotherapy. We compared three representative treatment plans using proton transmission beams versus conformal static-gantry photon beams. It was found that proton treatment plans using transmission beams passing through the patient were feasible and demonstrated lower dose to normal structures and markedly reduced treatment times than photon plans. This is the first study to demonstrate the feasibility of proton-based stereotactic ablative radiotherapy planning for lung tumors using proton transmission beams alone. Further research using this novel approach for proton-based planning is warranted.
format	article
author	Benjamin Mou Chris J Beltran Sean S Park Kenneth R Olivier Keith M Furutani
author_facet	Benjamin Mou Chris J Beltran Sean S Park Kenneth R Olivier Keith M Furutani
author_sort	Benjamin Mou
title	Feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.
title_short	Feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.
title_full	Feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.
title_fullStr	Feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.
title_full_unstemmed	Feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.
title_sort	feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/60acd1a3f1734f14b8b1a024b939f1f2
work_keys_str_mv	AT benjaminmou feasibilityofprotontransmissionbeamstereotacticablativeradiotherapyversusphotonstereotacticablativeradiotherapyforlungtumorsadosimetricandfeasibilitystudy AT chrisjbeltran feasibilityofprotontransmissionbeamstereotacticablativeradiotherapyversusphotonstereotacticablativeradiotherapyforlungtumorsadosimetricandfeasibilitystudy AT seanspark feasibilityofprotontransmissionbeamstereotacticablativeradiotherapyversusphotonstereotacticablativeradiotherapyforlungtumorsadosimetricandfeasibilitystudy AT kennethrolivier feasibilityofprotontransmissionbeamstereotacticablativeradiotherapyversusphotonstereotacticablativeradiotherapyforlungtumorsadosimetricandfeasibilitystudy AT keithmfurutani feasibilityofprotontransmissionbeamstereotacticablativeradiotherapyversusphotonstereotacticablativeradiotherapyforlungtumorsadosimetricandfeasibilitystudy
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Feasibility of proton transmission-beam stereotactic ablative radiotherapy versus photon stereotactic ablative radiotherapy for lung tumors: a dosimetric and feasibility study.

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