Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions

Winnie W Leung1, Margaret M McClure1, Larry J Siever1,2, Deanna M Barch3, Philip D Harvey1,21Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center (MIRECC), Bronx, NY, USA; 2Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA; 3Departmen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Winnie W Leung, Margaret M McClure, Larry J Siever, Deanna M Barch, Philip D Harvey
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/60adb83b630e4b09825329500b026dda
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:60adb83b630e4b09825329500b026dda
record_format	dspace
spelling	oai:doaj.org-article:60adb83b630e4b09825329500b026dda2021-12-02T03:49:03ZCatechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions1176-63281178-2021https://doaj.org/article/60adb83b630e4b09825329500b026dda2007-01-01T00:00:00Zhttp://www.dovepress.com/catechol-o-methyltransferase-val158met-genotype-in-healthy-and-persona-a972https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Winnie W Leung1, Margaret M McClure1, Larry J Siever1,2, Deanna M Barch3, Philip D Harvey1,21Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center (MIRECC), Bronx, NY, USA; 2Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA; 3Departments of Psychology and Psychiatry, Washington University, St. Louis, MO, USAAbstract: A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. However, previous studies have not examined the effects of COMT on context processing, as measured by the AX-CPT, a task hypothesized to be maximally relevant to DA function. 32 individuals who were either healthy, with schizotypal personality disorder, or non-cluster A, personality disorder (OPD) were genotyped at the COMT Val158Met locus. Met/Met (n = 6), Val/Met (n = 10), Val/Val (n = 16) individuals were administered a neuropsychological battery, including the AX-CPT and the N-back working memory test. For the AX-CPT, Met/Met demonstrated more AY errors (reflecting good maintenance of context) than the other genotypes, who showed equivalent error rates. Val/Val demonstrated disproportionately greater deterioration with increased task difficulty from 0-back to 1-back working memory demands as compared to Met/Met, while Val/Met did not differ from either genotypes. No differences were found on processing speed or verbal working memory. Both context processing and working memory appear related to COMT genotype and the AX-CPT and N-back may be most sensitive to the effects of COMT variation.Keywords: COMT, dopamine, context processing, working memory, schizotypal personality disorder Winnie W LeungMargaret M McClureLarry J SieverDeanna M BarchPhilip D HarveyDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2007, Iss Issue 6, Pp 925-934 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Winnie W Leung Margaret M McClure Larry J Siever Deanna M Barch Philip D Harvey Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
description	Winnie W Leung1, Margaret M McClure1, Larry J Siever1,2, Deanna M Barch3, Philip D Harvey1,21Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center (MIRECC), Bronx, NY, USA; 2Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA; 3Departments of Psychology and Psychiatry, Washington University, St. Louis, MO, USAAbstract: A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. However, previous studies have not examined the effects of COMT on context processing, as measured by the AX-CPT, a task hypothesized to be maximally relevant to DA function. 32 individuals who were either healthy, with schizotypal personality disorder, or non-cluster A, personality disorder (OPD) were genotyped at the COMT Val158Met locus. Met/Met (n = 6), Val/Met (n = 10), Val/Val (n = 16) individuals were administered a neuropsychological battery, including the AX-CPT and the N-back working memory test. For the AX-CPT, Met/Met demonstrated more AY errors (reflecting good maintenance of context) than the other genotypes, who showed equivalent error rates. Val/Val demonstrated disproportionately greater deterioration with increased task difficulty from 0-back to 1-back working memory demands as compared to Met/Met, while Val/Met did not differ from either genotypes. No differences were found on processing speed or verbal working memory. Both context processing and working memory appear related to COMT genotype and the AX-CPT and N-back may be most sensitive to the effects of COMT variation.Keywords: COMT, dopamine, context processing, working memory, schizotypal personality disorder
format	article
author	Winnie W Leung Margaret M McClure Larry J Siever Deanna M Barch Philip D Harvey
author_facet	Winnie W Leung Margaret M McClure Larry J Siever Deanna M Barch Philip D Harvey
author_sort	Winnie W Leung
title	Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
title_short	Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
title_full	Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
title_fullStr	Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
title_full_unstemmed	Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
title_sort	catechol-o-methyltransferase val158met genotype in healthy and personality disorder individuals: preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/60adb83b630e4b09825329500b026dda
work_keys_str_mv	AT winniewleung catecholomethyltransferaseval158metgenotypeinhealthyandpersonalitydisorderindividualspreliminaryresultsfromanexaminationofcognitivetestshypotheticallydifferentiallysensitivetodopaminefunctions AT margaretmmcclure catecholomethyltransferaseval158metgenotypeinhealthyandpersonalitydisorderindividualspreliminaryresultsfromanexaminationofcognitivetestshypotheticallydifferentiallysensitivetodopaminefunctions AT larryjsiever catecholomethyltransferaseval158metgenotypeinhealthyandpersonalitydisorderindividualspreliminaryresultsfromanexaminationofcognitivetestshypotheticallydifferentiallysensitivetodopaminefunctions AT deannambarch catecholomethyltransferaseval158metgenotypeinhealthyandpersonalitydisorderindividualspreliminaryresultsfromanexaminationofcognitivetestshypotheticallydifferentiallysensitivetodopaminefunctions AT philipdharvey catecholomethyltransferaseval158metgenotypeinhealthyandpersonalitydisorderindividualspreliminaryresultsfromanexaminationofcognitivetestshypotheticallydifferentiallysensitivetodopaminefunctions
_version_	1718401602680782848

Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions

Ejemplares similares