MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES

Specific perinatal infections make about 30% in causal structure of infant mortality. Among the respiratory diseases of perinatal period, pneumonias take a special place, due to higher frequency, severity, complications and adverse outcomes. The aim of this work was to study microflora and factors o...

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Autores principales:	O. A. Svitich, S. M. Omarova, A. I. Alieva, N. D. Rasskazova, V. V. Zverev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	newborns ventilator-associated infections intrauterine pneumonia antimicrobial peptides cytokines innate immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/60af42535911457ca970da8e7386773a
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spelling	oai:doaj.org-article:60af42535911457ca970da8e7386773a2021-11-18T08:03:45ZMUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES1563-06252313-741X10.15789/1563-0625-2016-2-163-170https://doaj.org/article/60af42535911457ca970da8e7386773a2016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/999https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSpecific perinatal infections make about 30% in causal structure of infant mortality. Among the respiratory diseases of perinatal period, pneumonias take a special place, due to higher frequency, severity, complications and adverse outcomes. The aim of this work was to study microflora and factors of innate immunity (TLR2, TLR4, HBD-1, HBD-2, TNFα and NF-kB) at the level of the mucous membranes of the upper respiratory tract during intrauterine infection of fetus and perinatal pneumonia. Causal structure of ventilator-associated pneumonias at the intensive care unit represents a broad spectrum of pathogens with high resistance to antibiotics. Changes of immunological parameters (recognizing structures, i.e., TLR2, TLR4, HBD-1; HBD-2 defensins; proinflammatory TNFα cytokine and NF-kB transcription factor) in patients with intrauterine infections and pneumonia are ambiguous. Decreased expression of TLR2, TLR4 genes, along with increased of TNFα and NF-kB gene expression. These changes correlate with type of infectious pathogen, thus allowing us to assume that the pathogen, due to pathogenicity factors, may directly affect innate immunity mechanisms.O. A. SvitichS. M. OmarovaA. I. AlievaN. D. RasskazovaV. V. ZverevSPb RAACIarticlenewbornsventilator-associated infectionsintrauterine pneumoniaantimicrobial peptidescytokinesinnate immunityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 2, Pp 163-170 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	newborns ventilator-associated infections intrauterine pneumonia antimicrobial peptides cytokines innate immunity Immunologic diseases. Allergy RC581-607
spellingShingle	newborns ventilator-associated infections intrauterine pneumonia antimicrobial peptides cytokines innate immunity Immunologic diseases. Allergy RC581-607 O. A. Svitich S. M. Omarova A. I. Alieva N. D. Rasskazova V. V. Zverev MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES
description	Specific perinatal infections make about 30% in causal structure of infant mortality. Among the respiratory diseases of perinatal period, pneumonias take a special place, due to higher frequency, severity, complications and adverse outcomes. The aim of this work was to study microflora and factors of innate immunity (TLR2, TLR4, HBD-1, HBD-2, TNFα and NF-kB) at the level of the mucous membranes of the upper respiratory tract during intrauterine infection of fetus and perinatal pneumonia. Causal structure of ventilator-associated pneumonias at the intensive care unit represents a broad spectrum of pathogens with high resistance to antibiotics. Changes of immunological parameters (recognizing structures, i.e., TLR2, TLR4, HBD-1; HBD-2 defensins; proinflammatory TNFα cytokine and NF-kB transcription factor) in patients with intrauterine infections and pneumonia are ambiguous. Decreased expression of TLR2, TLR4 genes, along with increased of TNFα and NF-kB gene expression. These changes correlate with type of infectious pathogen, thus allowing us to assume that the pathogen, due to pathogenicity factors, may directly affect innate immunity mechanisms.
format	article
author	O. A. Svitich S. M. Omarova A. I. Alieva N. D. Rasskazova V. V. Zverev
author_facet	O. A. Svitich S. M. Omarova A. I. Alieva N. D. Rasskazova V. V. Zverev
author_sort	O. A. Svitich
title	MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES
title_short	MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES
title_full	MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES
title_fullStr	MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES
title_full_unstemmed	MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES
title_sort	mucosal microflora and innate immunity of upper respiratory tract in intrauterine foetal infection and pneumonia of neonates
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/60af42535911457ca970da8e7386773a
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_version_	1718422421121269760

MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES

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