Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease

Abstract Human non-mercaptalbumin (HNA), oxidized form of serum albumin, has been reported as a useful marker in oxidative stress-related diseases; however, few reports have examined the association between HNA and the severity of coronary artery disease (CAD). The present study evaluated whether th...

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Autores principales:	Shengpu Chou, Keiko Yasukawa, Yusuke Fujino, Midori Ishibashi, Mikiko Haraguchi, Masaya Sato, Hitoshi Ikeda, Sunao Nakamura, Yutaka Yatomi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60b2d6eb2f6344cabce52dc7f19bbf57
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spelling	oai:doaj.org-article:60b2d6eb2f6344cabce52dc7f19bbf572021-12-02T15:22:57ZNon-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease10.1038/s41598-021-93753-02045-2322https://doaj.org/article/60b2d6eb2f6344cabce52dc7f19bbf572021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93753-0https://doaj.org/toc/2045-2322Abstract Human non-mercaptalbumin (HNA), oxidized form of serum albumin, has been reported as a useful marker in oxidative stress-related diseases; however, few reports have examined the association between HNA and the severity of coronary artery disease (CAD). The present study evaluated whether the HNA fraction is correlated with coronary artery stenosis in 140 patients considered to have a high risk of CAD or who were suspected of having acute coronary syndrome. The severity of CAD was defined by the number of stenotic coronary vessels and a severity score system (the Gensini score). HNA measurements were performed using our newly established high-performance liquid chromatography methodology. The results had shown that HNA was significantly increased in patients with three-vessel disease, compared with those without CAD or with single-vessel disease (p = 0.025), and was positively correlated with the Gensini score (ρ = 0.421, p < 0.001). A multivariate analysis showed that the number of stenotic vessels was an independent and significant factor associated with HNA (ρ = 1.246, p = 0.012). A logistic regression analysis showed that HNA was a strong predictor of multivessel CAD (odds ratio, 1.12; 95% confidence interval, 1.020–1.229; p = 0.017). These findings indicate that the measurement of HNA could be clinically practical for predicting the severity of coronary artery stenosis.Shengpu ChouKeiko YasukawaYusuke FujinoMidori IshibashiMikiko HaraguchiMasaya SatoHitoshi IkedaSunao NakamuraYutaka YatomiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shengpu Chou Keiko Yasukawa Yusuke Fujino Midori Ishibashi Mikiko Haraguchi Masaya Sato Hitoshi Ikeda Sunao Nakamura Yutaka Yatomi Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease
description	Abstract Human non-mercaptalbumin (HNA), oxidized form of serum albumin, has been reported as a useful marker in oxidative stress-related diseases; however, few reports have examined the association between HNA and the severity of coronary artery disease (CAD). The present study evaluated whether the HNA fraction is correlated with coronary artery stenosis in 140 patients considered to have a high risk of CAD or who were suspected of having acute coronary syndrome. The severity of CAD was defined by the number of stenotic coronary vessels and a severity score system (the Gensini score). HNA measurements were performed using our newly established high-performance liquid chromatography methodology. The results had shown that HNA was significantly increased in patients with three-vessel disease, compared with those without CAD or with single-vessel disease (p = 0.025), and was positively correlated with the Gensini score (ρ = 0.421, p < 0.001). A multivariate analysis showed that the number of stenotic vessels was an independent and significant factor associated with HNA (ρ = 1.246, p = 0.012). A logistic regression analysis showed that HNA was a strong predictor of multivessel CAD (odds ratio, 1.12; 95% confidence interval, 1.020–1.229; p = 0.017). These findings indicate that the measurement of HNA could be clinically practical for predicting the severity of coronary artery stenosis.
format	article
author	Shengpu Chou Keiko Yasukawa Yusuke Fujino Midori Ishibashi Mikiko Haraguchi Masaya Sato Hitoshi Ikeda Sunao Nakamura Yutaka Yatomi
author_facet	Shengpu Chou Keiko Yasukawa Yusuke Fujino Midori Ishibashi Mikiko Haraguchi Masaya Sato Hitoshi Ikeda Sunao Nakamura Yutaka Yatomi
author_sort	Shengpu Chou
title	Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease
title_short	Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease
title_full	Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease
title_fullStr	Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease
title_full_unstemmed	Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease
title_sort	non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/60b2d6eb2f6344cabce52dc7f19bbf57
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Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease

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