Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect

Abstract Carbon nanotubes (CNTs) are cylindrical nanostructures and have unique properties, including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn) as a possible substrate promoting peripheral nerve regeneration with...

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Autores principales:	Atsushi Kunisaki, Akira Kodama, Masakazu Ishikawa, Takahiro Ueda, Marcio D. Lima, Takeshi Kondo, Nobuo Adachi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60b3fb98a8c34cec90fe7e8c7259ea61
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spelling	oai:doaj.org-article:60b3fb98a8c34cec90fe7e8c7259ea612021-12-02T17:18:22ZCarbon-nanotube yarns induce axonal regeneration in peripheral nerve defect10.1038/s41598-021-98603-72045-2322https://doaj.org/article/60b3fb98a8c34cec90fe7e8c7259ea612021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98603-7https://doaj.org/toc/2045-2322Abstract Carbon nanotubes (CNTs) are cylindrical nanostructures and have unique properties, including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn) as a possible substrate promoting peripheral nerve regeneration with these properties. We bridged a 15 mm rat sciatic nerve defect with five different densities of cYarn. Eight weeks after the surgery, the regenerated axons crossing the CNTs, electromyographical findings, and muscle weight ratio of the lower leg showed recovery of the nerve function by interfacing with cYarn. Furthermore, the sciatic nerve functional index (SFI) at 16 weeks showed improvement in gait function. A 2% CNT density tended to be the most effective for nerve regeneration as measured by both histological axonal regeneration and motor function. We confirmed that CNT yarn promotes peripheral nerve regeneration by using it as a scaffold for repairing nerve defects. Our results support the future clinical application of CNTs for bridging nerve defects as an off-the-shelf material.Atsushi KunisakiAkira KodamaMasakazu IshikawaTakahiro UedaMarcio D. LimaTakeshi KondoNobuo AdachiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atsushi Kunisaki Akira Kodama Masakazu Ishikawa Takahiro Ueda Marcio D. Lima Takeshi Kondo Nobuo Adachi Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect
description	Abstract Carbon nanotubes (CNTs) are cylindrical nanostructures and have unique properties, including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn) as a possible substrate promoting peripheral nerve regeneration with these properties. We bridged a 15 mm rat sciatic nerve defect with five different densities of cYarn. Eight weeks after the surgery, the regenerated axons crossing the CNTs, electromyographical findings, and muscle weight ratio of the lower leg showed recovery of the nerve function by interfacing with cYarn. Furthermore, the sciatic nerve functional index (SFI) at 16 weeks showed improvement in gait function. A 2% CNT density tended to be the most effective for nerve regeneration as measured by both histological axonal regeneration and motor function. We confirmed that CNT yarn promotes peripheral nerve regeneration by using it as a scaffold for repairing nerve defects. Our results support the future clinical application of CNTs for bridging nerve defects as an off-the-shelf material.
format	article
author	Atsushi Kunisaki Akira Kodama Masakazu Ishikawa Takahiro Ueda Marcio D. Lima Takeshi Kondo Nobuo Adachi
author_facet	Atsushi Kunisaki Akira Kodama Masakazu Ishikawa Takahiro Ueda Marcio D. Lima Takeshi Kondo Nobuo Adachi
author_sort	Atsushi Kunisaki
title	Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect
title_short	Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect
title_full	Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect
title_fullStr	Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect
title_full_unstemmed	Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect
title_sort	carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/60b3fb98a8c34cec90fe7e8c7259ea61
work_keys_str_mv	AT atsushikunisaki carbonnanotubeyarnsinduceaxonalregenerationinperipheralnervedefect AT akirakodama carbonnanotubeyarnsinduceaxonalregenerationinperipheralnervedefect AT masakazuishikawa carbonnanotubeyarnsinduceaxonalregenerationinperipheralnervedefect AT takahiroueda carbonnanotubeyarnsinduceaxonalregenerationinperipheralnervedefect AT marciodlima carbonnanotubeyarnsinduceaxonalregenerationinperipheralnervedefect AT takeshikondo carbonnanotubeyarnsinduceaxonalregenerationinperipheralnervedefect AT nobuoadachi carbonnanotubeyarnsinduceaxonalregenerationinperipheralnervedefect
_version_	1718381088701677568

Carbon-nanotube yarns induce axonal regeneration in peripheral nerve defect

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