Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer

Abstract Programmed cell death-1 (PDCD1/PD-1) and its ligand programmed cell death 1 ligand 1 (CD274/PD-L1) have been reported to suppress anti-tumor T cell-mediated immune responses. However, the clinical significance of CD274 in colorectal cancer were still elusive. We aim to clarify the relations...

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Autores principales:	Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Tsung-Wei Chen, Ying-Shu You, William Tzu-Liang Chen, K. S. Clifford Chao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Tumor-infiltrating Lymphocytes (TILs) Tumor CD73 Expression CD133 Tumor TIL Count Programmed Cell Death-ligand 1 Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60b9499f2bc84bfe8d239a86ad6ce23e
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spelling	oai:doaj.org-article:60b9499f2bc84bfe8d239a86ad6ce23e2021-12-02T15:08:19ZClinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer10.1038/s41598-018-33927-52045-2322https://doaj.org/article/60b9499f2bc84bfe8d239a86ad6ce23e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33927-5https://doaj.org/toc/2045-2322Abstract Programmed cell death-1 (PDCD1/PD-1) and its ligand programmed cell death 1 ligand 1 (CD274/PD-L1) have been reported to suppress anti-tumor T cell-mediated immune responses. However, the clinical significance of CD274 in colorectal cancer were still elusive. We aim to clarify the relationships between CD8+ intratumor-infiltrating lymphocytes (TILs) and CD274 as well as their prognostic values in stage II-III colon carcinoma. Tumor differentiation, perineural invasion (PNI), pN stage and DNA mismatch repair (MMR)-deficient were clearly correlated with CD8+ TILs counts within the tumor microenvironment (p < 0.0001). Furthermore, tumor differentiation and PNI were suggestively correlated with tumor CD274 expression (p = 0.02 and p = 0.0195). Tumor CD274 level was significantly correlated with higher CD8+ TILs (p < 0.0001) but was not associated with MMR-deficient status (p = 0.14). High tumor CD274 expression [hazard ratio (HR) = 2.16, 95% CI = 1.63–2.86, p < 0.0001] and CD8+ TILs [HR = 1.51, 95% CI = 1.19–1.91, p = 0.0007] were associated with improved disease-free survival and overall survival. Additionally, the subgroup of patients who had a high CD8+ TILs/tumor CD274 have better survival outcomes compared with other subgroups (71% vs 53%; p < 0.0001). Therefore, the CD8+ TILs counts and tumor CD274 may be prognostic factors to predict survival and therapeutic responses in stage II–III colon carcinoma patients.Chih-Yang HuangShu-Fen ChiangTao-Wei KeTsung-Wei ChenYing-Shu YouWilliam Tzu-Liang ChenK. S. Clifford ChaoNature PortfolioarticleTumor-infiltrating Lymphocytes (TILs)Tumor CD73 ExpressionCD133 TumorTIL CountProgrammed Cell Death-ligand 1MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tumor-infiltrating Lymphocytes (TILs) Tumor CD73 Expression CD133 Tumor TIL Count Programmed Cell Death-ligand 1 Medicine R Science Q
spellingShingle	Tumor-infiltrating Lymphocytes (TILs) Tumor CD73 Expression CD133 Tumor TIL Count Programmed Cell Death-ligand 1 Medicine R Science Q Chih-Yang Huang Shu-Fen Chiang Tao-Wei Ke Tsung-Wei Chen Ying-Shu You William Tzu-Liang Chen K. S. Clifford Chao Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer
description	Abstract Programmed cell death-1 (PDCD1/PD-1) and its ligand programmed cell death 1 ligand 1 (CD274/PD-L1) have been reported to suppress anti-tumor T cell-mediated immune responses. However, the clinical significance of CD274 in colorectal cancer were still elusive. We aim to clarify the relationships between CD8+ intratumor-infiltrating lymphocytes (TILs) and CD274 as well as their prognostic values in stage II-III colon carcinoma. Tumor differentiation, perineural invasion (PNI), pN stage and DNA mismatch repair (MMR)-deficient were clearly correlated with CD8+ TILs counts within the tumor microenvironment (p < 0.0001). Furthermore, tumor differentiation and PNI were suggestively correlated with tumor CD274 expression (p = 0.02 and p = 0.0195). Tumor CD274 level was significantly correlated with higher CD8+ TILs (p < 0.0001) but was not associated with MMR-deficient status (p = 0.14). High tumor CD274 expression [hazard ratio (HR) = 2.16, 95% CI = 1.63–2.86, p < 0.0001] and CD8+ TILs [HR = 1.51, 95% CI = 1.19–1.91, p = 0.0007] were associated with improved disease-free survival and overall survival. Additionally, the subgroup of patients who had a high CD8+ TILs/tumor CD274 have better survival outcomes compared with other subgroups (71% vs 53%; p < 0.0001). Therefore, the CD8+ TILs counts and tumor CD274 may be prognostic factors to predict survival and therapeutic responses in stage II–III colon carcinoma patients.
format	article
author	Chih-Yang Huang Shu-Fen Chiang Tao-Wei Ke Tsung-Wei Chen Ying-Shu You William Tzu-Liang Chen K. S. Clifford Chao
author_facet	Chih-Yang Huang Shu-Fen Chiang Tao-Wei Ke Tsung-Wei Chen Ying-Shu You William Tzu-Liang Chen K. S. Clifford Chao
author_sort	Chih-Yang Huang
title	Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer
title_short	Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer
title_full	Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer
title_fullStr	Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer
title_full_unstemmed	Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer
title_sort	clinical significance of programmed death 1 ligand-1 (cd274/pd-l1) and intra-tumoral cd8+ t-cell infiltration in stage ii–iii colorectal cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/60b9499f2bc84bfe8d239a86ad6ce23e
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Clinical significance of programmed death 1 ligand-1 (CD274/PD-L1) and intra-tumoral CD8+ T-cell infiltration in stage II–III colorectal cancer

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