Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Cancer cells have been shown to be dependent upon glutamine for growth. Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an amino acid exchange factor.

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Autores principales:	Abigail S. Krall, Shili Xu, Thomas G. Graeber, Daniel Braas, Heather R. Christofk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60bac93b7d0d4ccbba58a39386a3ee0d
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spelling	oai:doaj.org-article:60bac93b7d0d4ccbba58a39386a3ee0d2021-12-02T14:39:51ZAsparagine promotes cancer cell proliferation through use as an amino acid exchange factor10.1038/ncomms114572041-1723https://doaj.org/article/60bac93b7d0d4ccbba58a39386a3ee0d2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11457https://doaj.org/toc/2041-1723Cancer cells have been shown to be dependent upon glutamine for growth. Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an amino acid exchange factor.Abigail S. KrallShili XuThomas G. GraeberDaniel BraasHeather R. ChristofkNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abigail S. Krall Shili Xu Thomas G. Graeber Daniel Braas Heather R. Christofk Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
description	Cancer cells have been shown to be dependent upon glutamine for growth. Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an amino acid exchange factor.
format	article
author	Abigail S. Krall Shili Xu Thomas G. Graeber Daniel Braas Heather R. Christofk
author_facet	Abigail S. Krall Shili Xu Thomas G. Graeber Daniel Braas Heather R. Christofk
author_sort	Abigail S. Krall
title	Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
title_short	Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
title_full	Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
title_fullStr	Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
title_full_unstemmed	Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
title_sort	asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/60bac93b7d0d4ccbba58a39386a3ee0d
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Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

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