Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Cancer cells have been shown to be dependent upon glutamine for growth. Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an amino acid exchange factor.

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Autores principales: Abigail S. Krall, Shili Xu, Thomas G. Graeber, Daniel Braas, Heather R. Christofk
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/60bac93b7d0d4ccbba58a39386a3ee0d
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