Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study

Binbin Zhao,1,&ast; Yanhua Wu,2,&ast; Xiaoying Jin,1 Lihong Yang,2 Jian Yang,1,2 Xiancang Ma,1 Bin Yan1,2 1Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, The First Affiliated Ho...

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Autores principales:	Zhao B, Wu Y, Jin X, Yang L, Yang J, Ma X, Yan B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	sleep characteristics ischemic stroke polysomnography sleep heart health study Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/60bad220056c4bf283eb00ff0f5c65eb
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spelling	oai:doaj.org-article:60bad220056c4bf283eb00ff0f5c65eb2021-12-02T16:46:28ZObjectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study1179-1608https://doaj.org/article/60bad220056c4bf283eb00ff0f5c65eb2021-08-01T00:00:00Zhttps://www.dovepress.com/objectively-measured-sleep-characteristics-and-incidence-of-ischemic-s-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Binbin Zhao,1,&ast; Yanhua Wu,2,&ast; Xiaoying Jin,1 Lihong Yang,2 Jian Yang,1,2 Xiancang Ma,1 Bin Yan1,2 1Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bin YanDepartment of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaTel +86 2985323614Email yanbin.1987@hotmail.comObjective: Sleep disorders are associated with the prevalence of stroke. However, there is limited evidence regarding the association between objectively measured sleep characteristics and ischemic stroke.Methods: Ischemic stroke was assessed during the mean follow-up period of 11 years in the Sleep Heart Health Study. Sleep parameters such as wake after sleep onset (WASO) and sleep efficiency (SE) were objectively measured based on in-home polysomnography records. Multivariable Cox regression analysis was utilized to examine the relationship between objective sleep characteristics and ischemic stroke incidence.Results: This study involved 4204 participants (1978 males and 2226 females, 63.8± 11.1 years). The incidence of ischemic stroke increased in individuals with long WASO, poor SE, and short sleep duration. Multivariable Cox regression analysis showed that WASO within the fourth quartile (hazard ratio [HR] 3.771, 95% confidence interval [CI] 1.805– 7.877, P< 0.001), third quartile (HR 3.009, 95% CI 1.433– 6.317, P=0.004), and second quartile (HR 3.108, 95% CI 1.470– 6.568, P=0.003) had a higher incidence of ischemic stroke than WASO within the first quartile. Poor SE (< 80.0%) was also found to be a predictor for ischemic stroke (HR 2.220, 95% CI 1.244– 3.960, P=0.007). Additionally, a short sleep duration (< 6 h) was associated with an increased risk of ischemic stroke (HR 1.725, 95% CI 1.026– 2.899, P=0.040).Conclusion: Our results revealed a relationship between WASO, SE, and sleep duration and ischemic stroke. Therefore, these sleep characteristics may be adequate predictors for the incidence of ischemic stroke.Keywords: sleep characteristics, ischemic stroke, polysomnography, Sleep Heart Health StudyZhao BWu YJin XYang LYang JMa XYan BDove Medical Pressarticlesleep characteristicsischemic strokepolysomnographysleep heart health studyPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1485-1494 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep characteristics ischemic stroke polysomnography sleep heart health study Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	sleep characteristics ischemic stroke polysomnography sleep heart health study Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Zhao B Wu Y Jin X Yang L Yang J Ma X Yan B Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study
description	Binbin Zhao,1,&ast; Yanhua Wu,2,&ast; Xiaoying Jin,1 Lihong Yang,2 Jian Yang,1,2 Xiancang Ma,1 Bin Yan1,2 1Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bin YanDepartment of Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaTel +86 2985323614Email yanbin.1987@hotmail.comObjective: Sleep disorders are associated with the prevalence of stroke. However, there is limited evidence regarding the association between objectively measured sleep characteristics and ischemic stroke.Methods: Ischemic stroke was assessed during the mean follow-up period of 11 years in the Sleep Heart Health Study. Sleep parameters such as wake after sleep onset (WASO) and sleep efficiency (SE) were objectively measured based on in-home polysomnography records. Multivariable Cox regression analysis was utilized to examine the relationship between objective sleep characteristics and ischemic stroke incidence.Results: This study involved 4204 participants (1978 males and 2226 females, 63.8± 11.1 years). The incidence of ischemic stroke increased in individuals with long WASO, poor SE, and short sleep duration. Multivariable Cox regression analysis showed that WASO within the fourth quartile (hazard ratio [HR] 3.771, 95% confidence interval [CI] 1.805– 7.877, P< 0.001), third quartile (HR 3.009, 95% CI 1.433– 6.317, P=0.004), and second quartile (HR 3.108, 95% CI 1.470– 6.568, P=0.003) had a higher incidence of ischemic stroke than WASO within the first quartile. Poor SE (< 80.0%) was also found to be a predictor for ischemic stroke (HR 2.220, 95% CI 1.244– 3.960, P=0.007). Additionally, a short sleep duration (< 6 h) was associated with an increased risk of ischemic stroke (HR 1.725, 95% CI 1.026– 2.899, P=0.040).Conclusion: Our results revealed a relationship between WASO, SE, and sleep duration and ischemic stroke. Therefore, these sleep characteristics may be adequate predictors for the incidence of ischemic stroke.Keywords: sleep characteristics, ischemic stroke, polysomnography, Sleep Heart Health Study
format	article
author	Zhao B Wu Y Jin X Yang L Yang J Ma X Yan B
author_facet	Zhao B Wu Y Jin X Yang L Yang J Ma X Yan B
author_sort	Zhao B
title	Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study
title_short	Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study
title_full	Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study
title_fullStr	Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study
title_full_unstemmed	Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study
title_sort	objectively measured sleep characteristics and incidence of ischemic stroke: the sleep heart health study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/60bad220056c4bf283eb00ff0f5c65eb
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Objectively Measured Sleep Characteristics and Incidence of Ischemic Stroke: The Sleep Heart Health Study

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