Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.

While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the gre...

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Autores principales:	Sharnel Perera, David Crewther, Rodney Croft, Hannah Keage, Daniel Hermens, C Richard Clark
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60bbdde004bc43b3961b36435852ba24
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spelling	oai:doaj.org-article:60bbdde004bc43b3961b36435852ba242021-11-18T07:05:58ZComorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.1932-620310.1371/journal.pone.0041407https://doaj.org/article/60bbdde004bc43b3961b36435852ba242012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22984398/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP) and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD) groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child group (age range 6 to 12; 52 Controls and 64 AD/HD) and from an adolescent group (age range 13 to 17; 79 Controls and 88 AD/HD) were reduced via a Principal Components Analysis, the 6 significant eigenvectors then used as determinants of cluster membership via a Two-Step Cluster Analysis. Two clusters were found in the analysis of the adolescent age group--a cluster dominated by Control and AD/HD participants without comorbidity, while the second cluster was dominated by AD/HD participants with externalising comorbidity (largely oppositional defiant/conduct disorder ODD/CD). A similar segregation within the child age group was not found. Further analysis of these objectively determined clusters in terms of their clinical diagnoses indicates a significant effect of ODD/CD comorbidity on a concurrent AD/HD diagnosis. We conclude that comorbid externalising behaviour in AD/HD constitutes a distinct pathological entity in adolescence.Sharnel PereraDavid CrewtherRodney CroftHannah KeageDaniel HermensC Richard ClarkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e41407 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sharnel Perera David Crewther Rodney Croft Hannah Keage Daniel Hermens C Richard Clark Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.
description	While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP) and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD) groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child group (age range 6 to 12; 52 Controls and 64 AD/HD) and from an adolescent group (age range 13 to 17; 79 Controls and 88 AD/HD) were reduced via a Principal Components Analysis, the 6 significant eigenvectors then used as determinants of cluster membership via a Two-Step Cluster Analysis. Two clusters were found in the analysis of the adolescent age group--a cluster dominated by Control and AD/HD participants without comorbidity, while the second cluster was dominated by AD/HD participants with externalising comorbidity (largely oppositional defiant/conduct disorder ODD/CD). A similar segregation within the child age group was not found. Further analysis of these objectively determined clusters in terms of their clinical diagnoses indicates a significant effect of ODD/CD comorbidity on a concurrent AD/HD diagnosis. We conclude that comorbid externalising behaviour in AD/HD constitutes a distinct pathological entity in adolescence.
format	article
author	Sharnel Perera David Crewther Rodney Croft Hannah Keage Daniel Hermens C Richard Clark
author_facet	Sharnel Perera David Crewther Rodney Croft Hannah Keage Daniel Hermens C Richard Clark
author_sort	Sharnel Perera
title	Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.
title_short	Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.
title_full	Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.
title_fullStr	Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.
title_full_unstemmed	Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.
title_sort	comorbid externalising behaviour in ad/hd: evidence for a distinct pathological entity in adolescence.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/60bbdde004bc43b3961b36435852ba24
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Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence.

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