Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway.
Deep brain stimulation (DBS) for Parkinson's disease often alleviates the motor symptoms, but causes cognitive and emotional side effects in a substantial number of cases. Identification of the motor part of the subthalamic nucleus (STN) as part of the presurgical workup could minimize these ad...
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2012
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oai:doaj.org-article:60bf5387db244872a8e7c91cc5c85f062021-11-18T07:14:00ZStructural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway.1932-620310.1371/journal.pone.0039061https://doaj.org/article/60bf5387db244872a8e7c91cc5c85f062012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22768059/?tool=EBIhttps://doaj.org/toc/1932-6203Deep brain stimulation (DBS) for Parkinson's disease often alleviates the motor symptoms, but causes cognitive and emotional side effects in a substantial number of cases. Identification of the motor part of the subthalamic nucleus (STN) as part of the presurgical workup could minimize these adverse effects. In this study, we assessed the STN's connectivity to motor, associative, and limbic brain areas, based on structural and functional connectivity analysis of volunteer data. For the structural connectivity, we used streamline counts derived from HARDI fiber tracking. The resulting tracks supported the existence of the so-called "hyperdirect" pathway in humans. Furthermore, we determined the connectivity of each STN voxel with the motor cortical areas. Functional connectivity was calculated based on functional MRI, as the correlation of the signal within a given brain voxel with the signal in the STN. Also, the signal per STN voxel was explained in terms of the correlation with motor or limbic brain seed ROI areas. Both right and left STN ROIs appeared to be structurally and functionally connected to brain areas that are part of the motor, associative, and limbic circuit. Furthermore, this study enabled us to assess the level of segregation of the STN motor part, which is relevant for the planning of STN DBS procedures.Ellen J L BrunenbergPim MoeskopsWalter H BackesClaudio PolloLeila CammounAnna VilanovaMarcus L F JanssenVeerle E R M Visser-VandewalleBart M ter Haar RomenyJean-Philippe ThiranBram PlatelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39061 (2012) |
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Medicine R Science Q |
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Medicine R Science Q Ellen J L Brunenberg Pim Moeskops Walter H Backes Claudio Pollo Leila Cammoun Anna Vilanova Marcus L F Janssen Veerle E R M Visser-Vandewalle Bart M ter Haar Romeny Jean-Philippe Thiran Bram Platel Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway. |
| description |
Deep brain stimulation (DBS) for Parkinson's disease often alleviates the motor symptoms, but causes cognitive and emotional side effects in a substantial number of cases. Identification of the motor part of the subthalamic nucleus (STN) as part of the presurgical workup could minimize these adverse effects. In this study, we assessed the STN's connectivity to motor, associative, and limbic brain areas, based on structural and functional connectivity analysis of volunteer data. For the structural connectivity, we used streamline counts derived from HARDI fiber tracking. The resulting tracks supported the existence of the so-called "hyperdirect" pathway in humans. Furthermore, we determined the connectivity of each STN voxel with the motor cortical areas. Functional connectivity was calculated based on functional MRI, as the correlation of the signal within a given brain voxel with the signal in the STN. Also, the signal per STN voxel was explained in terms of the correlation with motor or limbic brain seed ROI areas. Both right and left STN ROIs appeared to be structurally and functionally connected to brain areas that are part of the motor, associative, and limbic circuit. Furthermore, this study enabled us to assess the level of segregation of the STN motor part, which is relevant for the planning of STN DBS procedures. |
| format |
article |
| author |
Ellen J L Brunenberg Pim Moeskops Walter H Backes Claudio Pollo Leila Cammoun Anna Vilanova Marcus L F Janssen Veerle E R M Visser-Vandewalle Bart M ter Haar Romeny Jean-Philippe Thiran Bram Platel |
| author_facet |
Ellen J L Brunenberg Pim Moeskops Walter H Backes Claudio Pollo Leila Cammoun Anna Vilanova Marcus L F Janssen Veerle E R M Visser-Vandewalle Bart M ter Haar Romeny Jean-Philippe Thiran Bram Platel |
| author_sort |
Ellen J L Brunenberg |
| title |
Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway. |
| title_short |
Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway. |
| title_full |
Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway. |
| title_fullStr |
Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway. |
| title_full_unstemmed |
Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway. |
| title_sort |
structural and resting state functional connectivity of the subthalamic nucleus: identification of motor stn parts and the hyperdirect pathway. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/60bf5387db244872a8e7c91cc5c85f06 |
| work_keys_str_mv |
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