Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study

Michael K Smolek,1 Neil F Notaroberto,1,2 Arley G Jaramillo,1,2 Lisa R Pradillo1,2 1CLEVER Eye Institute, 2EyeCare 20/20, Slidell, LA, USA Background: The purpose of this study was to determine whether a combination of vitamins B6, B9, and B12 is an effective intervention for reducing the signs and...

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Autores principales:	Smolek MK, Notaroberto NF, Jaramillo AG, Pradillo LR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/60c362eeed3a48a6a61b4147dd0ea8a5
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spelling	oai:doaj.org-article:60c362eeed3a48a6a61b4147dd0ea8a52021-12-02T01:24:38ZIntervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study1177-54671177-5483https://doaj.org/article/60c362eeed3a48a6a61b4147dd0ea8a52013-07-01T00:00:00Zhttp://www.dovepress.com/intervention-with-vitamins-in-patients-with-nonproliferative-diabetic--a13679https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Michael K Smolek,1 Neil F Notaroberto,1,2 Arley G Jaramillo,1,2 Lisa R Pradillo1,2 1CLEVER Eye Institute, 2EyeCare 20/20, Slidell, LA, USA Background: The purpose of this study was to determine whether a combination of vitamins B6, B9, and B12 is an effective intervention for reducing the signs and symptoms of nonproliferative diabetic retinopathy. Methods: Ten subjects with type 2 diabetes mellitus (n = 20 eyes) with clinically diagnosed mild to moderate nonproliferative diabetic retinopathy were recruited from a private practice ophthalmology clinic for this open-label, uncontrolled, prospective six-month study. Metanx® vitamin tablets (containing 3 mg L-methylfolate calcium, 35 mg pyridoxal-5′-phosphate, and 2 mg methylcobalamin) were administered at a dosage of two tablets daily. Primary outcome indicators were the percent change in mean retinal sensitivity threshold measured by macular microperimetry and the percent change in mean central retinal thickness measured by spectral-domain optical coherence tomography. Results: Three subjects were lost to follow-up. In the remaining seven subjects, two of 14 eyes had foveal edema that prevented microperimetry measurements due to poor fixation. The remaining 12 eyes showed a nonlinear improvement in mean threshold retinal sensitivity (P < 0.001). Overall change in mean central retinal thickness in 14 eyes was linear (R2 = 0.625; P = 0.034), with a significant reduction between one and six months (P = 0.012). Conclusion: In this pilot study, the Metanx intervention appeared to have some beneficial effects with respect to reducing retinal edema and increasing light sensitivity in subjects with nonproliferative diabetic retinopathy. Keywords: diabetes, diabetic retinopathy, vitamin B, homocysteine, nitric oxide, microperimetrySmolek MKNotaroberto NFJaramillo AGPradillo LRDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1451-1458 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Smolek MK Notaroberto NF Jaramillo AG Pradillo LR Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study
description	Michael K Smolek,1 Neil F Notaroberto,1,2 Arley G Jaramillo,1,2 Lisa R Pradillo1,2 1CLEVER Eye Institute, 2EyeCare 20/20, Slidell, LA, USA Background: The purpose of this study was to determine whether a combination of vitamins B6, B9, and B12 is an effective intervention for reducing the signs and symptoms of nonproliferative diabetic retinopathy. Methods: Ten subjects with type 2 diabetes mellitus (n = 20 eyes) with clinically diagnosed mild to moderate nonproliferative diabetic retinopathy were recruited from a private practice ophthalmology clinic for this open-label, uncontrolled, prospective six-month study. Metanx® vitamin tablets (containing 3 mg L-methylfolate calcium, 35 mg pyridoxal-5′-phosphate, and 2 mg methylcobalamin) were administered at a dosage of two tablets daily. Primary outcome indicators were the percent change in mean retinal sensitivity threshold measured by macular microperimetry and the percent change in mean central retinal thickness measured by spectral-domain optical coherence tomography. Results: Three subjects were lost to follow-up. In the remaining seven subjects, two of 14 eyes had foveal edema that prevented microperimetry measurements due to poor fixation. The remaining 12 eyes showed a nonlinear improvement in mean threshold retinal sensitivity (P < 0.001). Overall change in mean central retinal thickness in 14 eyes was linear (R2 = 0.625; P = 0.034), with a significant reduction between one and six months (P = 0.012). Conclusion: In this pilot study, the Metanx intervention appeared to have some beneficial effects with respect to reducing retinal edema and increasing light sensitivity in subjects with nonproliferative diabetic retinopathy. Keywords: diabetes, diabetic retinopathy, vitamin B, homocysteine, nitric oxide, microperimetry
format	article
author	Smolek MK Notaroberto NF Jaramillo AG Pradillo LR
author_facet	Smolek MK Notaroberto NF Jaramillo AG Pradillo LR
author_sort	Smolek MK
title	Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study
title_short	Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study
title_full	Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study
title_fullStr	Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study
title_full_unstemmed	Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study
title_sort	intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/60c362eeed3a48a6a61b4147dd0ea8a5
work_keys_str_mv	AT smolekmk interventionwithvitaminsinpatientswithnonproliferativediabeticretinopathyapilotstudy AT notarobertonf interventionwithvitaminsinpatientswithnonproliferativediabeticretinopathyapilotstudy AT jaramilloag interventionwithvitaminsinpatientswithnonproliferativediabeticretinopathyapilotstudy AT pradillolr interventionwithvitaminsinpatientswithnonproliferativediabeticretinopathyapilotstudy
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Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study

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