Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

ten Klooster et al. use ileum-derived organoids and report that bacterial and viral stimuli can drive IL22 production by T cells via distinct signaling pathways, and that IL22 can stimulate expression of anti-microbial and antiviral factors. This study sheds light on how enterocytes, fibroblasts and...

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Autores principales:	Jean Paul ten Klooster, Marianne Bol-Schoenmakers, Kitty van Summeren, Arno L. W. van Vliet, Cornelis A. M. de Haan, Frank J. M. van Kuppeveld, Saertje Verkoeijen, Raymond Pieters
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/60c64a2589874380b2adeb1328a5a8e9
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spelling	oai:doaj.org-article:60c64a2589874380b2adeb1328a5a8e92021-12-02T15:49:50ZEnterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine10.1038/s42003-021-02176-02399-3642https://doaj.org/article/60c64a2589874380b2adeb1328a5a8e92021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02176-0https://doaj.org/toc/2399-3642ten Klooster et al. use ileum-derived organoids and report that bacterial and viral stimuli can drive IL22 production by T cells via distinct signaling pathways, and that IL22 can stimulate expression of anti-microbial and antiviral factors. This study sheds light on how enterocytes, fibroblasts and myeloid cells work synergistically to induce IL22 response against both bacteria and viruses.Jean Paul ten KloosterMarianne Bol-SchoenmakersKitty van SummerenArno L. W. van VlietCornelis A. M. de HaanFrank J. M. van KuppeveldSaertje VerkoeijenRaymond PietersNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jean Paul ten Klooster Marianne Bol-Schoenmakers Kitty van Summeren Arno L. W. van Vliet Cornelis A. M. de Haan Frank J. M. van Kuppeveld Saertje Verkoeijen Raymond Pieters Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
description	ten Klooster et al. use ileum-derived organoids and report that bacterial and viral stimuli can drive IL22 production by T cells via distinct signaling pathways, and that IL22 can stimulate expression of anti-microbial and antiviral factors. This study sheds light on how enterocytes, fibroblasts and myeloid cells work synergistically to induce IL22 response against both bacteria and viruses.
format	article
author	Jean Paul ten Klooster Marianne Bol-Schoenmakers Kitty van Summeren Arno L. W. van Vliet Cornelis A. M. de Haan Frank J. M. van Kuppeveld Saertje Verkoeijen Raymond Pieters
author_facet	Jean Paul ten Klooster Marianne Bol-Schoenmakers Kitty van Summeren Arno L. W. van Vliet Cornelis A. M. de Haan Frank J. M. van Kuppeveld Saertje Verkoeijen Raymond Pieters
author_sort	Jean Paul ten Klooster
title	Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
title_short	Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
title_full	Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
title_fullStr	Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
title_full_unstemmed	Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
title_sort	enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with il22 as the central cytokine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/60c64a2589874380b2adeb1328a5a8e9
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Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

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