Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
ten Klooster et al. use ileum-derived organoids and report that bacterial and viral stimuli can drive IL22 production by T cells via distinct signaling pathways, and that IL22 can stimulate expression of anti-microbial and antiviral factors. This study sheds light on how enterocytes, fibroblasts and...
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Autores principales: | Jean Paul ten Klooster, Marianne Bol-Schoenmakers, Kitty van Summeren, Arno L. W. van Vliet, Cornelis A. M. de Haan, Frank J. M. van Kuppeveld, Saertje Verkoeijen, Raymond Pieters |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/60c64a2589874380b2adeb1328a5a8e9 |
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