Predictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia

Objectives: To examine the importance of perinatal and postnatal environmental factors on developmental and respiratory outcomes among preterm infants with bronchopulmonary dysplasia (BPD).Methods: Preterm infants (<32 weeks of gestation) born at a single tertiary medical center between 2012...

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Autores principales:	Iris Morag, Efrat Barkai, Yaara Wazana, Arnon Elizur, Orly Levkovitz Stern, Orna Staretz-Chacham, Shiran Pinchevski-Kadir, Noa Ofek Shlomai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	development outcomes preterm infant machine learning bronchopulmonary dysplasia Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/60cbe3e100ca4aed9b6b900f7149c3b6
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spelling	oai:doaj.org-article:60cbe3e100ca4aed9b6b900f7149c3b62021-12-01T14:10:17ZPredictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia2296-236010.3389/fped.2021.780518https://doaj.org/article/60cbe3e100ca4aed9b6b900f7149c3b62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.780518/fullhttps://doaj.org/toc/2296-2360Objectives: To examine the importance of perinatal and postnatal environmental factors on developmental and respiratory outcomes among preterm infants with bronchopulmonary dysplasia (BPD).Methods: Preterm infants (<32 weeks of gestation) born at a single tertiary medical center between 2012 and 2015 were included. Development was assessed at 12 months corrected age. Parents retrospectively completed a health and lifestyle questionnaire reviewing their child's health during the first 2 years of life. A linear regression model was applied to assess the effect of various perinatal and postnatal factors on development. A machine-learning algorithm was trained to assess factors affecting inhaler use.Results: Of 398 infants meeting the inclusion criteria, 208 qualified for the study: 152 (73.1%) with no BPD, 40 (19.2%) with mild BPD, and 16 (7.7%) with moderate-severe BPD. Those in the moderate-severe group were more likely to be male, have mothers who were less educated, and require longer ventilation periods and less time to regain birth weight. They were also more likely to have mothers with asthma/allergies and to have a parent who smoked. Those in the moderate-severe BPD group exhibited significantly lower developmental scores (85.2 ± 16.4) than the no-BPD group (99.3 ± 10.9) and the mild BPD group (97.8 ± 11.7, p < 0.008) as well as more frequent inhaler use (p = 0.0014) than those with no or mild BPD. In addition to perinatal factors, exposure to breast milk, income level and daycare attendance positively affected development. Exposure to cigarette smoke, allergies among family members and daycare attendance proved to be important factors in inhaler use frequency.Conclusions: Postnatal environmental factors are important in predicting and modifying early childhood outcomes among preterm infants.Iris MoragIris MoragEfrat BarkaiYaara WazanaArnon ElizurArnon ElizurOrly Levkovitz SternOrly Levkovitz SternOrna Staretz-ChachamShiran Pinchevski-KadirShiran Pinchevski-KadirNoa Ofek ShlomaiFrontiers Media S.A.articledevelopmentoutcomespreterm infantmachine learningbronchopulmonary dysplasiaPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	development outcomes preterm infant machine learning bronchopulmonary dysplasia Pediatrics RJ1-570
spellingShingle	development outcomes preterm infant machine learning bronchopulmonary dysplasia Pediatrics RJ1-570 Iris Morag Iris Morag Efrat Barkai Yaara Wazana Arnon Elizur Arnon Elizur Orly Levkovitz Stern Orly Levkovitz Stern Orna Staretz-Chacham Shiran Pinchevski-Kadir Shiran Pinchevski-Kadir Noa Ofek Shlomai Predictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia
description	Objectives: To examine the importance of perinatal and postnatal environmental factors on developmental and respiratory outcomes among preterm infants with bronchopulmonary dysplasia (BPD).Methods: Preterm infants (<32 weeks of gestation) born at a single tertiary medical center between 2012 and 2015 were included. Development was assessed at 12 months corrected age. Parents retrospectively completed a health and lifestyle questionnaire reviewing their child's health during the first 2 years of life. A linear regression model was applied to assess the effect of various perinatal and postnatal factors on development. A machine-learning algorithm was trained to assess factors affecting inhaler use.Results: Of 398 infants meeting the inclusion criteria, 208 qualified for the study: 152 (73.1%) with no BPD, 40 (19.2%) with mild BPD, and 16 (7.7%) with moderate-severe BPD. Those in the moderate-severe group were more likely to be male, have mothers who were less educated, and require longer ventilation periods and less time to regain birth weight. They were also more likely to have mothers with asthma/allergies and to have a parent who smoked. Those in the moderate-severe BPD group exhibited significantly lower developmental scores (85.2 ± 16.4) than the no-BPD group (99.3 ± 10.9) and the mild BPD group (97.8 ± 11.7, p < 0.008) as well as more frequent inhaler use (p = 0.0014) than those with no or mild BPD. In addition to perinatal factors, exposure to breast milk, income level and daycare attendance positively affected development. Exposure to cigarette smoke, allergies among family members and daycare attendance proved to be important factors in inhaler use frequency.Conclusions: Postnatal environmental factors are important in predicting and modifying early childhood outcomes among preterm infants.
format	article
author	Iris Morag Iris Morag Efrat Barkai Yaara Wazana Arnon Elizur Arnon Elizur Orly Levkovitz Stern Orly Levkovitz Stern Orna Staretz-Chacham Shiran Pinchevski-Kadir Shiran Pinchevski-Kadir Noa Ofek Shlomai
author_facet	Iris Morag Iris Morag Efrat Barkai Yaara Wazana Arnon Elizur Arnon Elizur Orly Levkovitz Stern Orly Levkovitz Stern Orna Staretz-Chacham Shiran Pinchevski-Kadir Shiran Pinchevski-Kadir Noa Ofek Shlomai
author_sort	Iris Morag
title	Predictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia
title_short	Predictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia
title_full	Predictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia
title_fullStr	Predictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia
title_full_unstemmed	Predictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia
title_sort	predictors of developmental and respiratory outcomes among preterm infants with bronchopulmonary dysplasia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/60cbe3e100ca4aed9b6b900f7149c3b6
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Predictors of Developmental and Respiratory Outcomes Among Preterm Infants With Bronchopulmonary Dysplasia

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