Increased platelet distribution width predicts poor prognosis in melanoma patients

Abstract Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patien...

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Autores principales:	Na Li, Zhiyong Diao, Xiaoyi Huang, Ye Niu, Tiemin Liu, Zhi-ping Liu, Rui-tao Wang, Kai-jiang Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/60cc895652a1452088dfd144198aa91d
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spelling	oai:doaj.org-article:60cc895652a1452088dfd144198aa91d2021-12-02T11:40:43ZIncreased platelet distribution width predicts poor prognosis in melanoma patients10.1038/s41598-017-03212-y2045-2322https://doaj.org/article/60cc895652a1452088dfd144198aa91d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03212-yhttps://doaj.org/toc/2045-2322Abstract Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patients with melanoma were retrospectively enrolled between January 2009 and December 2009. The relationship between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Of the 220 patients, high platelet distribution width (PDW) levels were observed in 63 (28.6%) patients. Increased PDW was associated with tumor subtype (P < 0.001). Survival curves found that patients with increased PDW had significantly shorter survival time than those with normal PDW (P < 0.001). Cox regression analysis revealed that elevated PDW was an independent prognostic factor for overall survival (hazard ratio, 2.480; 95% confidence interval [CI], 1.386–4.436, P = 0.002). In conclusion, PDW is easily available in routine blood test. Our findings indicated that PDW is an independent predictor and that it may also be a potential parameter for targeted therapy in melanoma.Na LiZhiyong DiaoXiaoyi HuangYe NiuTiemin LiuZhi-ping LiuRui-tao WangKai-jiang YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Na Li Zhiyong Diao Xiaoyi Huang Ye Niu Tiemin Liu Zhi-ping Liu Rui-tao Wang Kai-jiang Yu Increased platelet distribution width predicts poor prognosis in melanoma patients
description	Abstract Activated platelets promote cancer progression and metastasis. Nevertheless, the prognostic value of platelet indices in melanoma had been rarely reported. The aim of this study was to investigate the predictive significance of platelet indices in melanoma. A total of 220 consecutive patients with melanoma were retrospectively enrolled between January 2009 and December 2009. The relationship between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Of the 220 patients, high platelet distribution width (PDW) levels were observed in 63 (28.6%) patients. Increased PDW was associated with tumor subtype (P < 0.001). Survival curves found that patients with increased PDW had significantly shorter survival time than those with normal PDW (P < 0.001). Cox regression analysis revealed that elevated PDW was an independent prognostic factor for overall survival (hazard ratio, 2.480; 95% confidence interval [CI], 1.386–4.436, P = 0.002). In conclusion, PDW is easily available in routine blood test. Our findings indicated that PDW is an independent predictor and that it may also be a potential parameter for targeted therapy in melanoma.
format	article
author	Na Li Zhiyong Diao Xiaoyi Huang Ye Niu Tiemin Liu Zhi-ping Liu Rui-tao Wang Kai-jiang Yu
author_facet	Na Li Zhiyong Diao Xiaoyi Huang Ye Niu Tiemin Liu Zhi-ping Liu Rui-tao Wang Kai-jiang Yu
author_sort	Na Li
title	Increased platelet distribution width predicts poor prognosis in melanoma patients
title_short	Increased platelet distribution width predicts poor prognosis in melanoma patients
title_full	Increased platelet distribution width predicts poor prognosis in melanoma patients
title_fullStr	Increased platelet distribution width predicts poor prognosis in melanoma patients
title_full_unstemmed	Increased platelet distribution width predicts poor prognosis in melanoma patients
title_sort	increased platelet distribution width predicts poor prognosis in melanoma patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/60cc895652a1452088dfd144198aa91d
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_version_	1718395583578767360

Increased platelet distribution width predicts poor prognosis in melanoma patients

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