Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection

Recurrence can still occur even after radical resection of stage I colorectal cancer (CRC). This study aimed to identify subgroups with a high risk for recurrence in the stage I CRC. We retrospectively reviewed prospectively collected data of 1952 patients with stage I CRC after radical resection be...

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Autores principales:	Hye-Sol Jung, Seung-Bum Ryoo, Han-Ki Lim, Min Jung Kim, Sang Hui Moon, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stage I colorectal cancer recurrence risk factors survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/60ccb4766bbb40688e3c4d4d5b716902
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spelling	oai:doaj.org-article:60ccb4766bbb40688e3c4d4d5b7169022021-11-11T15:27:30ZTumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection10.3390/cancers132152942072-6694https://doaj.org/article/60ccb4766bbb40688e3c4d4d5b7169022021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5294https://doaj.org/toc/2072-6694Recurrence can still occur even after radical resection of stage I colorectal cancer (CRC). This study aimed to identify subgroups with a high risk for recurrence in the stage I CRC. We retrospectively reviewed prospectively collected data of 1952 patients with stage I CRC after radical resection between 2002 and 2017 at our institute. 1398 (colon, 903 (64.6%), rectum, 495 (35.4%)) were eligible for analysis. We analyzed the risk factors for recurrence and survival. During the follow-up period (median: 59 months), 63 (4.6%) had a recurrence. The recurrence rate of rectal cancer was significantly higher than that of colon cancer (8.5% vs. 2.3%). Left-sided tumors, T2, tumor size >5 cm, and lymphovascular invasion were independent risk factors of colon cancer recurrence. Male, preoperative carcinoembryonic antigen (CEA) ≥2.5 ng/mL, and harvested lymph nodes (LNs) <12 were independently associated with recurrence of rectal cancer. Recurrence affected OS (5-year OS: 97.1% vs. 67.6%). Despite curative resection, survival sharply decreased with recurrence. The risk factors for recurrence were different between colon and rectal cancer. Patients with a higher risk for recurrence should be candidates for more aggressive surveillance, even in early-stage CRC.Hye-Sol JungSeung-Bum RyooHan-Ki LimMin Jung KimSang Hui MoonJi Won ParkSeung-Yong JeongKyu Joo ParkMDPI AGarticlestage I colorectal cancerrecurrencerisk factorssurvivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5294, p 5294 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stage I colorectal cancer recurrence risk factors survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	stage I colorectal cancer recurrence risk factors survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hye-Sol Jung Seung-Bum Ryoo Han-Ki Lim Min Jung Kim Sang Hui Moon Ji Won Park Seung-Yong Jeong Kyu Joo Park Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection
description	Recurrence can still occur even after radical resection of stage I colorectal cancer (CRC). This study aimed to identify subgroups with a high risk for recurrence in the stage I CRC. We retrospectively reviewed prospectively collected data of 1952 patients with stage I CRC after radical resection between 2002 and 2017 at our institute. 1398 (colon, 903 (64.6%), rectum, 495 (35.4%)) were eligible for analysis. We analyzed the risk factors for recurrence and survival. During the follow-up period (median: 59 months), 63 (4.6%) had a recurrence. The recurrence rate of rectal cancer was significantly higher than that of colon cancer (8.5% vs. 2.3%). Left-sided tumors, T2, tumor size >5 cm, and lymphovascular invasion were independent risk factors of colon cancer recurrence. Male, preoperative carcinoembryonic antigen (CEA) ≥2.5 ng/mL, and harvested lymph nodes (LNs) <12 were independently associated with recurrence of rectal cancer. Recurrence affected OS (5-year OS: 97.1% vs. 67.6%). Despite curative resection, survival sharply decreased with recurrence. The risk factors for recurrence were different between colon and rectal cancer. Patients with a higher risk for recurrence should be candidates for more aggressive surveillance, even in early-stage CRC.
format	article
author	Hye-Sol Jung Seung-Bum Ryoo Han-Ki Lim Min Jung Kim Sang Hui Moon Ji Won Park Seung-Yong Jeong Kyu Joo Park
author_facet	Hye-Sol Jung Seung-Bum Ryoo Han-Ki Lim Min Jung Kim Sang Hui Moon Ji Won Park Seung-Yong Jeong Kyu Joo Park
author_sort	Hye-Sol Jung
title	Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection
title_short	Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection
title_full	Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection
title_fullStr	Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection
title_full_unstemmed	Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection
title_sort	tumor size >5 cm and harvested lns <12 are the risk factors for recurrence in stage i colon and rectal cancer after radical resection
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/60ccb4766bbb40688e3c4d4d5b716902
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Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection

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