Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis

Objective To evaluate the utility of Golgi protein 73 (GP73) in the diagnosis of non-alcoholic steatohepatitis (NASH) and hepatic fibrosis (HF) staging. Methods Ninety-one patients with non-alcoholic fatty liver disease (NAFLD) were allocated to NAFL (n = 46) and NASH (n = 45) groups according to th...

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Autores principales:	Yadi Li, Yan Yang, Yufang Li, Ping Zhang, Gaiying Ge, Jing Jin, Ting Du, Maiyan Ma, Li Na, Lu Ding, Huiping Sheng
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/60cd23d260914424a575ae045b443a29
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spelling	oai:doaj.org-article:60cd23d260914424a575ae045b443a292021-11-15T00:03:51ZUse of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis1473-230010.1177/03000605211055378https://doaj.org/article/60cd23d260914424a575ae045b443a292021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211055378https://doaj.org/toc/1473-2300Objective To evaluate the utility of Golgi protein 73 (GP73) in the diagnosis of non-alcoholic steatohepatitis (NASH) and hepatic fibrosis (HF) staging. Methods Ninety-one patients with non-alcoholic fatty liver disease (NAFLD) were allocated to NAFL (n = 46) and NASH (n = 45) groups according to their NAFLD activity score (NAS), and there were 30 healthy controls. Serum GP73 was measured by ELISA, GP73 protein expression was evaluated using immunohistochemistry, and FibroScan was used to determine liver hardness. Results The serum GP73 concentrations of the NAFL and NASH groups were significantly higher than those of controls. GP73 expression in the liver of the patients gradually progressed from absent or low to moderate or high. Serum GP73 positively correlated with liver expression, and the serum and liver GP73 of the patients positively correlated with FibroScan value and HF stage. There was a strong positive correlation of the combination of alanine aminotransferase, gamma glutamyl transferase and GP73 with NASH. The combination of serum GP73 and FibroScan value was found to predict NASH (NAS > 4) and advanced HF (stage ≥2) in patients with NAFLD using receiver operating characteristic analysis. Conclusion Serum GP73 may be useful in the diagnosis of NASH and the staging of HF.Yadi LiYan YangYufang LiPing ZhangGaiying GeJing JinTing DuMaiyan MaLi NaLu DingHuiping ShengSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yadi Li Yan Yang Yufang Li Ping Zhang Gaiying Ge Jing Jin Ting Du Maiyan Ma Li Na Lu Ding Huiping Sheng Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis
description	Objective To evaluate the utility of Golgi protein 73 (GP73) in the diagnosis of non-alcoholic steatohepatitis (NASH) and hepatic fibrosis (HF) staging. Methods Ninety-one patients with non-alcoholic fatty liver disease (NAFLD) were allocated to NAFL (n = 46) and NASH (n = 45) groups according to their NAFLD activity score (NAS), and there were 30 healthy controls. Serum GP73 was measured by ELISA, GP73 protein expression was evaluated using immunohistochemistry, and FibroScan was used to determine liver hardness. Results The serum GP73 concentrations of the NAFL and NASH groups were significantly higher than those of controls. GP73 expression in the liver of the patients gradually progressed from absent or low to moderate or high. Serum GP73 positively correlated with liver expression, and the serum and liver GP73 of the patients positively correlated with FibroScan value and HF stage. There was a strong positive correlation of the combination of alanine aminotransferase, gamma glutamyl transferase and GP73 with NASH. The combination of serum GP73 and FibroScan value was found to predict NASH (NAS > 4) and advanced HF (stage ≥2) in patients with NAFLD using receiver operating characteristic analysis. Conclusion Serum GP73 may be useful in the diagnosis of NASH and the staging of HF.
format	article
author	Yadi Li Yan Yang Yufang Li Ping Zhang Gaiying Ge Jing Jin Ting Du Maiyan Ma Li Na Lu Ding Huiping Sheng
author_facet	Yadi Li Yan Yang Yufang Li Ping Zhang Gaiying Ge Jing Jin Ting Du Maiyan Ma Li Na Lu Ding Huiping Sheng
author_sort	Yadi Li
title	Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis
title_short	Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis
title_full	Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis
title_fullStr	Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis
title_full_unstemmed	Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis
title_sort	use of gp73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/60cd23d260914424a575ae045b443a29
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Use of GP73 in the diagnosis of non-alcoholic steatohepatitis and the staging of hepatic fibrosis

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