IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms

IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms

Immunoglobulin (Ig) rearrangement and translocation information are usually obtained by targeted sequencing of the respective loci. Here, the authors present the IgCaller algorithm, which extracts Ig heavy and light chain genetic properties from short-read whole-genome sequencing results to provide...

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Autores principales: Ferran Nadeu, Rut Mas-de-les-Valls, Alba Navarro, Romina Royo, Silvia Martín, Neus Villamor, Helena Suárez-Cisneros, Rosó Mares, Junyan Lu, Anna Enjuanes, Alfredo Rivas-Delgado, Marta Aymerich, Tycho Baumann, Dolors Colomer, Julio Delgado, Ryan D. Morin, Thorsten Zenz, Xose S. Puente, Peter J. Campbell, Sílvia Beà, Francesco Maura, Elías Campo
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/60cf64de4d48413e9c6aa1237bafd86b
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spelling oai:doaj.org-article:60cf64de4d48413e9c6aa1237bafd86b2021-12-02T15:23:00ZIgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms10.1038/s41467-020-17095-72041-1723https://doaj.org/article/60cf64de4d48413e9c6aa1237bafd86b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17095-7https://doaj.org/toc/2041-1723Immunoglobulin (Ig) rearrangement and translocation information are usually obtained by targeted sequencing of the respective loci. Here, the authors present the IgCaller algorithm, which extracts Ig heavy and light chain genetic properties from short-read whole-genome sequencing results to provide a feasible alternative to direct sequencing.Ferran NadeuRut Mas-de-les-VallsAlba NavarroRomina RoyoSilvia MartínNeus VillamorHelena Suárez-CisnerosRosó MaresJunyan LuAnna EnjuanesAlfredo Rivas-DelgadoMarta AymerichTycho BaumannDolors ColomerJulio DelgadoRyan D. MorinThorsten ZenzXose S. PuentePeter J. CampbellSílvia BeàFrancesco MauraElías CampoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ferran Nadeu
Rut Mas-de-les-Valls
Alba Navarro
Romina Royo
Silvia Martín
Neus Villamor
Helena Suárez-Cisneros
Rosó Mares
Junyan Lu
Anna Enjuanes
Alfredo Rivas-Delgado
Marta Aymerich
Tycho Baumann
Dolors Colomer
Julio Delgado
Ryan D. Morin
Thorsten Zenz
Xose S. Puente
Peter J. Campbell
Sílvia Beà
Francesco Maura
Elías Campo
IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
description Immunoglobulin (Ig) rearrangement and translocation information are usually obtained by targeted sequencing of the respective loci. Here, the authors present the IgCaller algorithm, which extracts Ig heavy and light chain genetic properties from short-read whole-genome sequencing results to provide a feasible alternative to direct sequencing.
format article
author Ferran Nadeu
Rut Mas-de-les-Valls
Alba Navarro
Romina Royo
Silvia Martín
Neus Villamor
Helena Suárez-Cisneros
Rosó Mares
Junyan Lu
Anna Enjuanes
Alfredo Rivas-Delgado
Marta Aymerich
Tycho Baumann
Dolors Colomer
Julio Delgado
Ryan D. Morin
Thorsten Zenz
Xose S. Puente
Peter J. Campbell
Sílvia Beà
Francesco Maura
Elías Campo
author_facet Ferran Nadeu
Rut Mas-de-les-Valls
Alba Navarro
Romina Royo
Silvia Martín
Neus Villamor
Helena Suárez-Cisneros
Rosó Mares
Junyan Lu
Anna Enjuanes
Alfredo Rivas-Delgado
Marta Aymerich
Tycho Baumann
Dolors Colomer
Julio Delgado
Ryan D. Morin
Thorsten Zenz
Xose S. Puente
Peter J. Campbell
Sílvia Beà
Francesco Maura
Elías Campo
author_sort Ferran Nadeu
title IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
title_short IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
title_full IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
title_fullStr IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
title_full_unstemmed IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
title_sort igcaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/60cf64de4d48413e9c6aa1237bafd86b
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