Central nervous system toxicity of metallic nanoparticles

Xiaoli Feng,1 Aijie Chen,1 Yanli Zhang,1 Jianfeng Wang,2 Longquan Shao,1 Limin Wei2 1Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People’s Republic of Chin...

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Autores principales:	Feng XL, Chen AJ, Zhang YL, Wang JF, Shao LQ, Wei LM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/60d04d266b4a44c093351c57d2e3463a
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spelling	oai:doaj.org-article:60d04d266b4a44c093351c57d2e3463a2021-12-02T01:32:31ZCentral nervous system toxicity of metallic nanoparticles1178-2013https://doaj.org/article/60d04d266b4a44c093351c57d2e3463a2015-07-01T00:00:00Zhttp://www.dovepress.com/central-nervous-system-toxicity-of-metallic-nanoparticles-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaoli Feng,1 Aijie Chen,1 Yanli Zhang,1 Jianfeng Wang,2 Longquan Shao,1 Limin Wei2 1Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Nanomaterials (NMs) are increasingly used for the therapy, diagnosis, and monitoring of disease- or drug-induced mechanisms in the human biological system. In view of their small size, after certain modifications, NMs have the capacity to bypass or cross the blood–brain barrier. Nanotechnology is particularly advantageous in the field of neurology. Examples may include the utilization of nanoparticle (NP)-based drug carriers to readily cross the blood–brain barrier to treat central nervous system (CNS) diseases, nanoscaffolds for axonal regeneration, nanoelectromechanical systems in neurological operations, and NPs in molecular imaging and CNS imaging. However, NPs can also be potentially hazardous to the CNS in terms of nanoneurotoxicity via several possible mechanisms, such as oxidative stress, autophagy, and lysosome dysfunction, and the activation of certain signaling pathways. In this review, we discuss the dual effect of NMs on the CNS and the mechanisms involved. The limitations of the current research are also discussed. Keywords: nanomaterials, neurotoxicity, blood–brain barrier, autophagy, ROSFeng XLChen AJZhang YLWang JFShao LQWei LMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4321-4340 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Feng XL Chen AJ Zhang YL Wang JF Shao LQ Wei LM Central nervous system toxicity of metallic nanoparticles
description	Xiaoli Feng,1 Aijie Chen,1 Yanli Zhang,1 Jianfeng Wang,2 Longquan Shao,1 Limin Wei2 1Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People’s Republic of China Abstract: Nanomaterials (NMs) are increasingly used for the therapy, diagnosis, and monitoring of disease- or drug-induced mechanisms in the human biological system. In view of their small size, after certain modifications, NMs have the capacity to bypass or cross the blood–brain barrier. Nanotechnology is particularly advantageous in the field of neurology. Examples may include the utilization of nanoparticle (NP)-based drug carriers to readily cross the blood–brain barrier to treat central nervous system (CNS) diseases, nanoscaffolds for axonal regeneration, nanoelectromechanical systems in neurological operations, and NPs in molecular imaging and CNS imaging. However, NPs can also be potentially hazardous to the CNS in terms of nanoneurotoxicity via several possible mechanisms, such as oxidative stress, autophagy, and lysosome dysfunction, and the activation of certain signaling pathways. In this review, we discuss the dual effect of NMs on the CNS and the mechanisms involved. The limitations of the current research are also discussed. Keywords: nanomaterials, neurotoxicity, blood–brain barrier, autophagy, ROS
format	article
author	Feng XL Chen AJ Zhang YL Wang JF Shao LQ Wei LM
author_facet	Feng XL Chen AJ Zhang YL Wang JF Shao LQ Wei LM
author_sort	Feng XL
title	Central nervous system toxicity of metallic nanoparticles
title_short	Central nervous system toxicity of metallic nanoparticles
title_full	Central nervous system toxicity of metallic nanoparticles
title_fullStr	Central nervous system toxicity of metallic nanoparticles
title_full_unstemmed	Central nervous system toxicity of metallic nanoparticles
title_sort	central nervous system toxicity of metallic nanoparticles
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/60d04d266b4a44c093351c57d2e3463a
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Central nervous system toxicity of metallic nanoparticles

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