The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia

Background: Schizophrenia requires lifelong treatment; Second-generation Antipsychotics (SGAs) have become the most prescribed medication for schizophrenia patients. The efficacy of various SGAs treatment may differ in schizophrenia patients with various traditional Chinese medicine (TCM) body const...

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Autores principales:	Tzu-Pei Yeh, Li-Chi Huang, Yu-Fen Chen, Jui-Fen Cheng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	schizophrenia second-generation antipsychotics traditional Chinese medicine body constitutions Medicine R
Acceso en línea:	https://doaj.org/article/60d04f5eec0d4dd98a3a796ab5eca11d
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spelling	oai:doaj.org-article:60d04f5eec0d4dd98a3a796ab5eca11d2021-11-25T17:44:33ZThe Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia10.3390/healthcare91114802227-9032https://doaj.org/article/60d04f5eec0d4dd98a3a796ab5eca11d2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1480https://doaj.org/toc/2227-9032Background: Schizophrenia requires lifelong treatment; Second-generation Antipsychotics (SGAs) have become the most prescribed medication for schizophrenia patients. The efficacy of various SGAs treatment may differ in schizophrenia patients with various traditional Chinese medicine (TCM) body constitution (BC) types. Method: This study applied a longitudinal quantitative research design, where a total of 66 participants were recruited. The Positive and Negative Symptom Scale (PANSS) and the Clinical Global Impression (CGI) score were used to evaluate patients’ psychopathology status in hospitalization, and body constitution questionnaires were conducted by face-to-face interviews in the 1st, 3rd, and 6th week of hospitalization. Results: More than 60% of schizophrenia patients who were treated with SGAs were classified to have unbalanced BC types including Yin-Xu, Yang-Xu and Stasis. Generalized estimating equation analysis revealed significant time effects in CGI and PANSS score improvements in both unbalanced and gentleness (balance) BC types, but no significant changes in the group and group-time interaction in the CGI and PANSS scores in different BC type groups. Conclusions: Schizophrenia patients under SGAs treatment had a higher proportion of unbalanced BC types which may lead to poorer physical or mental statuses, such as overweight problems. Health care providers could apply interventions according to patients’ BC types for disease prevention.Tzu-Pei YehLi-Chi HuangYu-Fen ChenJui-Fen ChengMDPI AGarticleschizophreniasecond-generation antipsychoticstraditional Chinese medicinebody constitutionsMedicineRENHealthcare, Vol 9, Iss 1480, p 1480 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia second-generation antipsychotics traditional Chinese medicine body constitutions Medicine R
spellingShingle	schizophrenia second-generation antipsychotics traditional Chinese medicine body constitutions Medicine R Tzu-Pei Yeh Li-Chi Huang Yu-Fen Chen Jui-Fen Cheng The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia
description	Background: Schizophrenia requires lifelong treatment; Second-generation Antipsychotics (SGAs) have become the most prescribed medication for schizophrenia patients. The efficacy of various SGAs treatment may differ in schizophrenia patients with various traditional Chinese medicine (TCM) body constitution (BC) types. Method: This study applied a longitudinal quantitative research design, where a total of 66 participants were recruited. The Positive and Negative Symptom Scale (PANSS) and the Clinical Global Impression (CGI) score were used to evaluate patients’ psychopathology status in hospitalization, and body constitution questionnaires were conducted by face-to-face interviews in the 1st, 3rd, and 6th week of hospitalization. Results: More than 60% of schizophrenia patients who were treated with SGAs were classified to have unbalanced BC types including Yin-Xu, Yang-Xu and Stasis. Generalized estimating equation analysis revealed significant time effects in CGI and PANSS score improvements in both unbalanced and gentleness (balance) BC types, but no significant changes in the group and group-time interaction in the CGI and PANSS scores in different BC type groups. Conclusions: Schizophrenia patients under SGAs treatment had a higher proportion of unbalanced BC types which may lead to poorer physical or mental statuses, such as overweight problems. Health care providers could apply interventions according to patients’ BC types for disease prevention.
format	article
author	Tzu-Pei Yeh Li-Chi Huang Yu-Fen Chen Jui-Fen Cheng
author_facet	Tzu-Pei Yeh Li-Chi Huang Yu-Fen Chen Jui-Fen Cheng
author_sort	Tzu-Pei Yeh
title	The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia
title_short	The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia
title_full	The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia
title_fullStr	The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia
title_full_unstemmed	The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia
title_sort	relationship between the second-generation antipsychotics efficacy and the traditional chinese medicine body constitutions in patients with schizophrenia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/60d04f5eec0d4dd98a3a796ab5eca11d
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The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia

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