A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.

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Autores principales:	Tetsuro Yoshimaru, Masaya Ono, Yoshimi Bando, Yi-An Chen, Kenji Mizuguchi, Hiroshi Shima, Masato Komatsu, Issei Imoto, Keisuke Izumi, Junko Honda, Yasuo Miyoshi, Mitsunori Sasa, Toyomasa Katagiri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/60d347e4facc4c32a918af21f2d88d68
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spelling	oai:doaj.org-article:60d347e4facc4c32a918af21f2d88d682021-12-02T14:40:22ZA-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells10.1038/ncomms154272041-1723https://doaj.org/article/60d347e4facc4c32a918af21f2d88d682017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15427https://doaj.org/toc/2041-1723BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.Tetsuro YoshimaruMasaya OnoYoshimi BandoYi-An ChenKenji MizuguchiHiroshi ShimaMasato KomatsuIssei ImotoKeisuke IzumiJunko HondaYasuo MiyoshiMitsunori SasaToyomasa KatagiriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
description	BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.
format	article
author	Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri
author_facet	Tetsuro Yoshimaru Masaya Ono Yoshimi Bando Yi-An Chen Kenji Mizuguchi Hiroshi Shima Masato Komatsu Issei Imoto Keisuke Izumi Junko Honda Yasuo Miyoshi Mitsunori Sasa Toyomasa Katagiri
author_sort	Tetsuro Yoshimaru
title	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_short	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_full	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_fullStr	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_full_unstemmed	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
title_sort	a-kinase anchoring protein big3 coordinates oestrogen signalling in breast cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/60d347e4facc4c32a918af21f2d88d68
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A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

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