A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.

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Bibliographic Details
Main Authors: Tetsuro Yoshimaru, Masaya Ono, Yoshimi Bando, Yi-An Chen, Kenji Mizuguchi, Hiroshi Shima, Masato Komatsu, Issei Imoto, Keisuke Izumi, Junko Honda, Yasuo Miyoshi, Mitsunori Sasa, Toyomasa Katagiri
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/60d347e4facc4c32a918af21f2d88d68
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https://doaj.org/article/60d347e4facc4c32a918af21f2d88d68

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