The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica

(1) Polymyalgia rheumatica (PMR) is an inflammatory disease characterised by pain, morning stiffness, and reduced quality of life. Recently, vagus nerve stimulation (VNS) was shown to have anti-inflammatory effects. We aimed to examine the effect of transcutaneous VNS (t-VNS) on PMR. (2) Fifteen tre...

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Autores principales:	Jacob Venborg, Anne-Marie Wegeberg, Salome Kristensen, Birgitte Brock, Christina Brock, Mogens Pfeiffer-Jensen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polymyalgia rheumatica vagus nerve stimulation inflammatory response PMR t-vns Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/60d7f9aa2a1d4fc7927d438ff4fb340e
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spelling	oai:doaj.org-article:60d7f9aa2a1d4fc7927d438ff4fb340e2021-11-25T18:39:52ZThe Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica10.3390/ph141111661424-8247https://doaj.org/article/60d7f9aa2a1d4fc7927d438ff4fb340e2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1166https://doaj.org/toc/1424-8247(1) Polymyalgia rheumatica (PMR) is an inflammatory disease characterised by pain, morning stiffness, and reduced quality of life. Recently, vagus nerve stimulation (VNS) was shown to have anti-inflammatory effects. We aimed to examine the effect of transcutaneous VNS (t-VNS) on PMR. (2) Fifteen treatment-naïve PMR patients completed the study. Patients underwent a 5-day protocol, receiving 2 min of t-VNS stimulation bilaterally on the neck, three times daily. Cardiac vagal tone (CVT) measured on a linear vagal scale (LVS), blood pressure, heart rate, patient-reported outcome, and biochemical changes were assessed. (3) t-VNS induced a 22% increase in CVT at 20 min after initial stimulations compared with baseline (3.4 ± 2.2 LVS vs. 4.1 ± 2.9 LVS, <i>p</i> = 0.02) and was accompanied by a 4 BPM reduction in heart rate (73 ± 11 BPM vs. 69 ± 9, <i>p</i> < 0.01). No long-term effects were observed. Furthermore, t-VNS induced a 14% reduction in the VAS score for the hips at day 5 compared with the baseline (5.1 ± 2.8 vs. 4.4 ± 2.8, <i>p</i> = 0.04). No changes in CRP or proinflammatory analytes were observed. (4) t-VNS modulates the autonomic nervous system in patients with PMR, but further investigation of t-VNS in PMR patients is warranted.Jacob VenborgAnne-Marie WegebergSalome KristensenBirgitte BrockChristina BrockMogens Pfeiffer-JensenMDPI AGarticlepolymyalgia rheumaticavagus nerve stimulationinflammatory responsePMRt-vnsMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1166, p 1166 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymyalgia rheumatica vagus nerve stimulation inflammatory response PMR t-vns Medicine R Pharmacy and materia medica RS1-441
spellingShingle	polymyalgia rheumatica vagus nerve stimulation inflammatory response PMR t-vns Medicine R Pharmacy and materia medica RS1-441 Jacob Venborg Anne-Marie Wegeberg Salome Kristensen Birgitte Brock Christina Brock Mogens Pfeiffer-Jensen The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica
description	(1) Polymyalgia rheumatica (PMR) is an inflammatory disease characterised by pain, morning stiffness, and reduced quality of life. Recently, vagus nerve stimulation (VNS) was shown to have anti-inflammatory effects. We aimed to examine the effect of transcutaneous VNS (t-VNS) on PMR. (2) Fifteen treatment-naïve PMR patients completed the study. Patients underwent a 5-day protocol, receiving 2 min of t-VNS stimulation bilaterally on the neck, three times daily. Cardiac vagal tone (CVT) measured on a linear vagal scale (LVS), blood pressure, heart rate, patient-reported outcome, and biochemical changes were assessed. (3) t-VNS induced a 22% increase in CVT at 20 min after initial stimulations compared with baseline (3.4 ± 2.2 LVS vs. 4.1 ± 2.9 LVS, <i>p</i> = 0.02) and was accompanied by a 4 BPM reduction in heart rate (73 ± 11 BPM vs. 69 ± 9, <i>p</i> < 0.01). No long-term effects were observed. Furthermore, t-VNS induced a 14% reduction in the VAS score for the hips at day 5 compared with the baseline (5.1 ± 2.8 vs. 4.4 ± 2.8, <i>p</i> = 0.04). No changes in CRP or proinflammatory analytes were observed. (4) t-VNS modulates the autonomic nervous system in patients with PMR, but further investigation of t-VNS in PMR patients is warranted.
format	article
author	Jacob Venborg Anne-Marie Wegeberg Salome Kristensen Birgitte Brock Christina Brock Mogens Pfeiffer-Jensen
author_facet	Jacob Venborg Anne-Marie Wegeberg Salome Kristensen Birgitte Brock Christina Brock Mogens Pfeiffer-Jensen
author_sort	Jacob Venborg
title	The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica
title_short	The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica
title_full	The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica
title_fullStr	The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica
title_full_unstemmed	The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica
title_sort	effect of transcutaneous vagus nerve stimulation in patients with polymyalgia rheumatica
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/60d7f9aa2a1d4fc7927d438ff4fb340e
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The Effect of Transcutaneous Vagus Nerve Stimulation in Patients with Polymyalgia Rheumatica

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