15d-PGJ<sub>2</sub> Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay

15d-PGJ<sub>2</sub> Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay

Osteosarcoma (OS) is the most common type of bone tumor, and has limited therapy options. 15-Deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> (15d-PGJ<sub>2</sub>) has striking anti-tumor effects in various tumors. Here, we investigated molecular mechanisms tha...

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Detalles Bibliográficos
Autores principales: Mateja Mikulčić, Nassim Ghaffari Tabrizi-Wizsy, Eva M. Bernhart, Martin Asslaber, Christopher Trummer, Werner Windischhofer, Wolfgang Sattler, Ernst Malle, Andelko Hrzenjak
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
15d-PGJ<sub>2</sub>
apoptosis
CAM assay
osteosarcoma
reactive oxygen species
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/60d805b815b9430988f1f91da671a2fa
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