The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs

The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs

Gema Rebolleda, Alfonso Casado, Noelia Oblanca, Francisco J Muñoz-Negrete Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain Background and objective: To investigate and compare the false-positive (FP) diagnostic classification of the Bruch&r...

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Autores principales: Rebolleda G, Casado A, Oblanca N, Muñoz-Negrete FJ
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
tilted disc
optical coherence tomography
false-positive
Bruch membrane
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/60d88118d4b045efac86a86e59c3b3fb
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spelling oai:doaj.org-article:60d88118d4b045efac86a86e59c3b3fb2021-12-02T07:13:46ZThe new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs1177-5483https://doaj.org/article/60d88118d4b045efac86a86e59c3b3fb2016-12-01T00:00:00Zhttps://www.dovepress.com/the-new-bruchrsquos-membrane-opening-ndash-minimum-rim-width-classific-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Gema Rebolleda, Alfonso Casado, Noelia Oblanca, Francisco J Muñoz-Negrete Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain Background and objective: To investigate and compare the false-positive (FP) diagnostic classification of the Bruch’s membrane opening – minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in healthy eyes with tilted optic disc.Materials and methods: Fifty healthy eyes of 30 participants with tilted optic disc underwent BMO-MRW and RNFL scanning using Spectralis and macular Cirrus optical coherence tomography (OCT) scans.Results: The overall FP rate was significantly lower using BMO-MRW map compared with both RNFL map by Spectralis (8% vs 62%, respectively, P<0.001) and ganglion cell analysis (GCA) map by Cirrus (8% vs 50%, respectively, P<0.001). Specificity was significantly higher using BMO-MRW than RNFL in eyes with low (89.7% vs 41.4%, P<0.001) and moderate myopia (95.2% vs 33.3%, P<0.001). Conclusion: OCT-derived BMO-MRW analysis provides significantly greater specificity than RNFL in tilted disc irrespectively of the refractive error, and it is more specific than GCA analysis in tilted disc with moderate myopia. Keywords: tilted disc, optical coherence tomography, false-positive, Bruch membraneRebolleda GCasado AOblanca NMuñoz-Negrete FJDove Medical Pressarticletilted discoptical coherence tomographyfalse-positiveBruch membraneOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 2417-2425 (2016)
institution DOAJ
collection DOAJ
language EN
topic tilted disc
optical coherence tomography
false-positive
Bruch membrane
Ophthalmology
RE1-994
spellingShingle tilted disc
optical coherence tomography
false-positive
Bruch membrane
Ophthalmology
RE1-994
Rebolleda G
Casado A
Oblanca N
Muñoz-Negrete FJ
The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs
description Gema Rebolleda, Alfonso Casado, Noelia Oblanca, Francisco J Muñoz-Negrete Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain Background and objective: To investigate and compare the false-positive (FP) diagnostic classification of the Bruch’s membrane opening – minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in healthy eyes with tilted optic disc.Materials and methods: Fifty healthy eyes of 30 participants with tilted optic disc underwent BMO-MRW and RNFL scanning using Spectralis and macular Cirrus optical coherence tomography (OCT) scans.Results: The overall FP rate was significantly lower using BMO-MRW map compared with both RNFL map by Spectralis (8% vs 62%, respectively, P<0.001) and ganglion cell analysis (GCA) map by Cirrus (8% vs 50%, respectively, P<0.001). Specificity was significantly higher using BMO-MRW than RNFL in eyes with low (89.7% vs 41.4%, P<0.001) and moderate myopia (95.2% vs 33.3%, P<0.001). Conclusion: OCT-derived BMO-MRW analysis provides significantly greater specificity than RNFL in tilted disc irrespectively of the refractive error, and it is more specific than GCA analysis in tilted disc with moderate myopia. Keywords: tilted disc, optical coherence tomography, false-positive, Bruch membrane
format article
author Rebolleda G
Casado A
Oblanca N
Muñoz-Negrete FJ
author_facet Rebolleda G
Casado A
Oblanca N
Muñoz-Negrete FJ
author_sort Rebolleda G
title The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs
title_short The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs
title_full The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs
title_fullStr The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs
title_full_unstemmed The new Bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs
title_sort new bruch’s membrane opening – minimum rim width classification improves optical coherence tomography specificity in tilted discs
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/60d88118d4b045efac86a86e59c3b3fb
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